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Substitution of histidine 95 by tyrosine in the prion protein causes spontaneous neurodegeneration in transgenic mice.

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Title: Substitution of histidine 95 by tyrosine in the prion protein causes spontaneous neurodegeneration in transgenic mice.
Authors: Torres JM; Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain., Marín-Moreno A; Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain., Espinosa JC; Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain., Canoyra S; Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain.; Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Complutense de Madrid UCM, Madrid, Spain., Burato A; Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy., Ciullini A; Unit of Laboratory of Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., De Luca CMG; Division of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Bistaffa E; Division of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Moda F; Unit of Laboratory of Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy., Legname G; Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy.; ELETTRA Sincrotrone Trieste S.C.p.A, Basovizza, Trieste, Italy.
Source: PLoS pathogens [PLoS Pathog] 2025 Oct 16; Vol. 21 (10), pp. e1013554. Date of Electronic Publication: 2025 Oct 16 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Substitution of histidine 95 by tyrosine in the prion protein causes spontaneous neurodegeneration in transgenic mice.
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  Data: <searchLink fieldCode="AU" term="%22Torres+JM%22">Torres JM</searchLink>; Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Marín-Moreno+A%22">Marín-Moreno A</searchLink>; Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Espinosa+JC%22">Espinosa JC</searchLink>; Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Canoyra+S%22">Canoyra S</searchLink>; Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain.; Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Complutense de Madrid UCM, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Burato+A%22">Burato A</searchLink>; Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Ciullini+A%22">Ciullini A</searchLink>; Unit of Laboratory of Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Luca+CMG%22">De Luca CMG</searchLink>; Division of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bistaffa+E%22">Bistaffa E</searchLink>; Division of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Moda+F%22">Moda F</searchLink>; Unit of Laboratory of Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Legname+G%22">Legname G</searchLink>; Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy.; ELETTRA Sincrotrone Trieste S.C.p.A, Basovizza, Trieste, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101238921%22">PLoS pathogens</searchLink> [PLoS Pathog] 2025 Oct 16; Vol. 21 (10), pp. e1013554. <i>Date of Electronic Publication: </i>2025 Oct 16 (<i>Print Publication: </i>2025).
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              Text: 2025 Oct 16
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