Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models.
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| Title: | Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models. |
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| Authors: | Xie Z; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Wang X; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Yan Y; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Steichen JM; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA., Ma KM; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA., Cottrell CA; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA., Melzi E; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Bottermann M; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Villavicencio PM; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Rantalainen K; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA., Schiffner T; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; Institute for Drug Discovery, Leipzig University Medical Faculty, Leipzig, 04103, Germany., Warner JE; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Weldon SR; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Prum T; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Ellis-Pugh JR; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Torres JL; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Jackson AM; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Flynn CT; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Ozorowski G; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Himansu S; Moderna Inc., Cambridge, MA 02142, USA., Carfi A; Moderna Inc., Cambridge, MA 02142, USA., Ward AB; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Nair U; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Schief WR; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; Moderna Inc., Cambridge, MA 02142, USA., Batista FD; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA. |
| Source: | Science immunology [Sci Immunol] 2025 Oct 17; Vol. 10 (112), pp. eadu7961. Date of Electronic Publication: 2025 Oct 17. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2470-9468 |
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| DOI: | 10.1126/sciimmunol.adu7961 |
