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Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models.

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Title: Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models.
Authors: Xie Z; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Wang X; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Yan Y; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Steichen JM; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA., Ma KM; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA., Cottrell CA; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA., Melzi E; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Bottermann M; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Villavicencio PM; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Rantalainen K; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA., Schiffner T; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; Institute for Drug Discovery, Leipzig University Medical Faculty, Leipzig, 04103, Germany., Warner JE; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Weldon SR; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Prum T; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Ellis-Pugh JR; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Torres JL; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Jackson AM; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Flynn CT; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Ozorowski G; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Himansu S; Moderna Inc., Cambridge, MA 02142, USA., Carfi A; Moderna Inc., Cambridge, MA 02142, USA., Ward AB; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Nair U; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Schief WR; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; Moderna Inc., Cambridge, MA 02142, USA., Batista FD; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Source: Science immunology [Sci Immunol] 2025 Oct 17; Vol. 10 (112), pp. eadu7961. Date of Electronic Publication: 2025 Oct 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models.
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  Data: <searchLink fieldCode="AU" term="%22Xie+Z%22">Xie Z</searchLink>; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Yan+Y%22">Yan Y</searchLink>; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Steichen+JM%22">Steichen JM</searchLink>; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Ma+KM%22">Ma KM</searchLink>; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Cottrell+CA%22">Cottrell CA</searchLink>; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Melzi+E%22">Melzi E</searchLink>; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Bottermann+M%22">Bottermann M</searchLink>; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Villavicencio+PM%22">Villavicencio PM</searchLink>; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Rantalainen+K%22">Rantalainen K</searchLink>; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Schiffner+T%22">Schiffner T</searchLink>; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; Institute for Drug Discovery, Leipzig University Medical Faculty, Leipzig, 04103, Germany.<br /><searchLink fieldCode="AU" term="%22Warner+JE%22">Warner JE</searchLink>; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Weldon+SR%22">Weldon SR</searchLink>; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Prum+T%22">Prum T</searchLink>; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Ellis-Pugh+JR%22">Ellis-Pugh JR</searchLink>; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Torres+JL%22">Torres JL</searchLink>; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Jackson+AM%22">Jackson AM</searchLink>; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Flynn+CT%22">Flynn CT</searchLink>; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Ozorowski+G%22">Ozorowski G</searchLink>; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Himansu+S%22">Himansu S</searchLink>; Moderna Inc., Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Carfi+A%22">Carfi A</searchLink>; Moderna Inc., Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Ward+AB%22">Ward AB</searchLink>; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Nair+U%22">Nair U</searchLink>; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Schief+WR%22">Schief WR</searchLink>; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; Moderna Inc., Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Batista+FD%22">Batista FD</searchLink>; Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
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