Efficacy and safety of Shugan Jieyu capsules in combination with zolpidem for insomnia disorder with depressive symptoms: a double-blind randomized controlled trial.
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| Title: | Efficacy and safety of Shugan Jieyu capsules in combination with zolpidem for insomnia disorder with depressive symptoms: a double-blind randomized controlled trial. |
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| Authors: | Xin Q; Department of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, No 1838, Guangzhou Northern Road, Guangzhou, Guangdong, 510515, China.; Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, 510515, China.; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, Guangdong, 510515, China., Paudel D; Department of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, No 1838, Guangzhou Northern Road, Guangzhou, Guangdong, 510515, China.; Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, 510515, China.; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, Guangdong, 510515, China., Zhang J; Shanxi Datong University School of Medicine, Datong, Shanxi, 037009, China., Wei H; Department of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, No 1838, Guangzhou Northern Road, Guangzhou, Guangdong, 510515, China.; Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, 510515, China.; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, Guangdong, 510515, China., Cheng Y; Department of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, No 1838, Guangzhou Northern Road, Guangzhou, Guangdong, 510515, China.; Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, 510515, China.; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, Guangdong, 510515, China., Xu Y; Department of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, No 1838, Guangzhou Northern Road, Guangzhou, Guangdong, 510515, China.; Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, 510515, China.; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, Guangdong, 510515, China., Fang R; Department of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, No 1838, Guangzhou Northern Road, Guangzhou, Guangdong, 510515, China.; Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, 510515, China.; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, Guangdong, 510515, China., Jiang J; Department of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, No 1838, Guangzhou Northern Road, Guangzhou, Guangdong, 510515, China.; Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, 510515, China.; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, Guangdong, 510515, China., Wang Y; Department of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, No 1838, Guangzhou Northern Road, Guangzhou, Guangdong, 510515, China.; Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, 510515, China.; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, Guangdong, 510515, China., Zhang B; Department of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, No 1838, Guangzhou Northern Road, Guangzhou, Guangdong, 510515, China. zhang73bin@hotmail.com.; Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, 510515, China. zhang73bin@hotmail.com.; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, Guangdong, 510515, China. zhang73bin@hotmail.com. |
| Source: | BMC complementary medicine and therapies [BMC Complement Med Ther] 2025 Oct 17; Vol. 25 (1), pp. 383. Date of Electronic Publication: 2025 Oct 17. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101761232 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-7671 (Electronic) Linking ISSN: 26627671 NLM ISO Abbreviation: BMC Complement Med Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2662-7671 |
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| DOI: | 10.1186/s12906-025-05142-z |
