A systematic review and meta-analysis to identify vertical limits for a high-dose opioid therapy.

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Title: A systematic review and meta-analysis to identify vertical limits for a high-dose opioid therapy.
Authors: Dickmann F; Department of Palliative Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany., Stingl J; Institute of Clinical Pharmacology, Medical Faculty University Heidelberg, Heidelberg, Germany., Lampert A; Institute of Neurophysiology, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Scientific Center for Neuropathic pain Aachen SCN AACHEN, Medical Faculty, RWTH Aachen University, Aachen, Germany., Mücke M; Institute for Digitalization and General Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Rare Diseases Aachen (ZSEA), Medical Faculty, RWTH Aachen University, Aachen, Germany., Peuckmann-Post V; Department of Anesthesiology, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Institute for Occupational, Social and Environmental Medicine, Medical Faculty RWTH, Aachen University, Aachen, Germany., Magerl W; Chair of Neurophysiology, Mannheim Center for Translational Neuroscience, Ruprecht Karls University Heidelberg, Mannheim, Germany., Rolke R; Department of Palliative Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.; Scientific Center for Neuropathic pain Aachen SCN AACHEN, Medical Faculty, RWTH Aachen University, Aachen, Germany., Weber S; Department of Palliative Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany. sasweber@ukaachen.de.; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen University, Aachen, Germany. sasweber@ukaachen.de.; Scientific Center for Neuropathic pain Aachen SCN AACHEN, Medical Faculty, RWTH Aachen University, Aachen, Germany. sasweber@ukaachen.de.
Source: Neurological research and practice [Neurol Res Pract] 2025 Oct 17; Vol. 7 (1), pp. 77. Date of Electronic Publication: 2025 Oct 17.
Publication Type: Journal Article; Review
Journal Info: Publisher: BMC Country of Publication: England NLM ID: 101767802 Publication Model: Electronic Cited Medium: Internet ISSN: 2524-3489 (Electronic) Linking ISSN: 25243489 NLM ISO Abbreviation: Neurol Res Pract Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2524-3489
DOI:10.1186/s42466-025-00437-5