Amifostine and melatonin attenuate radiation-induced oxidative stress, inflammation, and fibrotic remodeling in the vocal folds and subglottic glands of rats.

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Title: Amifostine and melatonin attenuate radiation-induced oxidative stress, inflammation, and fibrotic remodeling in the vocal folds and subglottic glands of rats.
Authors: Kim JM; Pusan National University Medical Research Institute, Pusan National University School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea. Electronic address: jimin-kim@pusan.ac.kr., Park GC; Department of Otolaryngology - Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, Republic of Korea. Electronic address: uuhent@skku.edu., Lee HW; Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, Republic of Korea. Electronic address: sudowo@skku.edu., Bang SY; Pusan National University Medical Research Institute, Pusan National University School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea. Electronic address: sooyoungbang@pusan.ac.kr., Kim DH; Department of Radiation Oncology, Pusan National University School of Medicine, Pusan National University and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea. Electronic address: dh2372@pusan.ac.kr., Kim WT; Department of Radiation Oncology, Pusan National University School of Medicine, Pusan National University and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea. Electronic address: radionco@pusan.ac.kr., Shin SC; Department of Otorhinolaryngology - Head and Neck Surgery, College of Medicine, Pusan National University and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea. Electronic address: shinsc0810@pusan.ac.kr., Cheon YI; Department of Otorhinolaryngology - Head and Neck Surgery, College of Medicine, Pusan National University and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea. Electronic address: skydragonone@pusan.ac.kr., Lee BJ; Department of Otorhinolaryngology-Head and Neck Surgery, Good Gang-An Hospital, Busan 48265, Republic of Korea. Electronic address: voicelee@pusan.ac.kr.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Nov; Vol. 192, pp. 118658. Date of Electronic Publication: 2025 Oct 18.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1950-6007
DOI:10.1016/j.biopha.2025.118658