Exemestane induces liver toxicity in zebrafish larvae by upregulating the p53 signaling pathway.

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Title: Exemestane induces liver toxicity in zebrafish larvae by upregulating the p53 signaling pathway.
Authors: Li W; College of Pharmacy, Nanchang University, Nanchang, China., Zhou X; College of Pharmacy, Nanchang University, Nanchang, China., Chen W; Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, Key Laboratory of Jiangxi Province for Biological Invasion and Biosecurity, Clinical Research Center of Affiliated Hospital, College of Life Sciences, Jinggangshan University, Ji'an, 343009, China., Hu W; Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, Key Laboratory of Jiangxi Province for Biological Invasion and Biosecurity, Clinical Research Center of Affiliated Hospital, College of Life Sciences, Jinggangshan University, Ji'an, 343009, China., Wang Z; Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, Key Laboratory of Jiangxi Province for Biological Invasion and Biosecurity, Clinical Research Center of Affiliated Hospital, College of Life Sciences, Jinggangshan University, Ji'an, 343009, China., Xiao Z; Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, Key Laboratory of Jiangxi Province for Biological Invasion and Biosecurity, Clinical Research Center of Affiliated Hospital, College of Life Sciences, Jinggangshan University, Ji'an, 343009, China., Yuan W; Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, Key Laboratory of Jiangxi Province for Biological Invasion and Biosecurity, Clinical Research Center of Affiliated Hospital, College of Life Sciences, Jinggangshan University, Ji'an, 343009, China., Lian J; Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, Key Laboratory of Jiangxi Province for Biological Invasion and Biosecurity, Clinical Research Center of Affiliated Hospital, College of Life Sciences, Jinggangshan University, Ji'an, 343009, China., Xiao J; Department of Ultrasound, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, 330006, Jiangxi, China., Cao Z; Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, Key Laboratory of Jiangxi Province for Biological Invasion and Biosecurity, Clinical Research Center of Affiliated Hospital, College of Life Sciences, Jinggangshan University, Ji'an, 343009, China. zigangcao@126.com., Zhang S; Department of General Surgery, Jiangxi Provincial Children's Hospital, The Affiliated Children's Hospital of Nanchang Medical College, Nanchang, Jiangxi, China. zshouhua416@163.com., Wang B; College of Pharmacy, Nanchang University, Nanchang, China. wbcy008@163.com.
Source: Fish physiology and biochemistry [Fish Physiol Biochem] 2025 Oct 20; Vol. 51 (6), pp. 177. Date of Electronic Publication: 2025 Oct 20.
Publication Type: Journal Article
Journal Info: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 100955049 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-5168 (Electronic) Linking ISSN: 09201742 NLM ISO Abbreviation: Fish Physiol Biochem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1573-5168
DOI:10.1007/s10695-025-01588-7