TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence.
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| Title: | TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence. |
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| Authors: | Kahlhofer J; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Marchet N; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Zubak K; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Seifert B; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Hotze M; Department of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, 6020, Austria., Egger-Hörschinger AS; Department of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, 6020, Austria., Kucej L; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Manzl C; Institute of Neuropathology & Neuromolecular Pathology, Medical University of Innsbruck, 6020, Innsbruck, Austria., Weyer Y; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Weys S; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.; Institute of Science and Technology Austria (ISTA), Klosterneuburg, 3400, Austria., Offterdinger M; Institute of Systems Neuroscience, BioOptics core facility, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Herzog S; Institute for Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Reiterer V; Institute of Pathophysiology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Volani C; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, 6020, Austria., Kwiatkowski M; Department of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, 6020, Austria., Wortmann SB; University Children's Hospital, Salzburger Landeskliniken and Paracelsus Medical University, Salzburg, 5020, Austria.; Amalia Children's Hospital, Department of Pediatrics, Pediatric Neurology, Nijmegen, The Netherlands., Nemati S; Kinder- und Jugendheilkunde, Krankenhaus St. Vinzenz Zams, Zams, 6511, Austria., Mayr JA; University Children's Hospital, Salzburger Landeskliniken and Paracelsus Medical University, Salzburg, 5020, Austria., Zschocke J; Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, 6020, Austria., Radlinger B; Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, 6020, Austria., Thedieck K; Department of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, 6020, Austria.; Department Metabolism, Senescence and Autophagy, Research Center One Health Ruhr, University Alliance Ruhr & University Hospital Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen, a partnership between German Cancer Research Center (DKFZ) and University Hospital Essen, Heidelberg, Germany.; Freiburg Materials Research Center (FMF), University Freiburg, Freiburg, Germany.; Laboratory of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Kremser L; Institute of Medical Biochemistry, Protein Core Facility, Medical University of Innsbruck, Innsbruck, Austria., Sarg B; Institute of Medical Biochemistry, Protein Core Facility, Medical University of Innsbruck, Innsbruck, Austria., Huber LA; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Farhan H; Institute of Pathophysiology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., de Araujo MEG; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Kaser S; Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, 6020, Austria., Scholl-Bürgi S; Department of Child and Adolescent Health, Division of Pediatrics I-Inherited Metabolic Disorders, Medical University of Innsbruck, Innsbruck, 6020, Austria., Karall D; Department of Child and Adolescent Health, Division of Pediatrics I-Inherited Metabolic Disorders, Medical University of Innsbruck, Innsbruck, 6020, Austria., Teis D; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria. david.teis@i-med.ac.at.; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria. david.teis@i-med.ac.at. |
| Source: | The EMBO journal [EMBO J] 2025 Dec; Vol. 44 (23), pp. 7119-7153. Date of Electronic Publication: 2025 Oct 20. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1460-2075 |
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| DOI: | 10.1038/s44318-025-00608-9 |
