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TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence.

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Title: TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence.
Authors: Kahlhofer J; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Marchet N; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Zubak K; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Seifert B; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Hotze M; Department of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, 6020, Austria., Egger-Hörschinger AS; Department of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, 6020, Austria., Kucej L; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Manzl C; Institute of Neuropathology & Neuromolecular Pathology, Medical University of Innsbruck, 6020, Innsbruck, Austria., Weyer Y; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Weys S; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.; Institute of Science and Technology Austria (ISTA), Klosterneuburg, 3400, Austria., Offterdinger M; Institute of Systems Neuroscience, BioOptics core facility, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Herzog S; Institute for Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Reiterer V; Institute of Pathophysiology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Volani C; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, 6020, Austria., Kwiatkowski M; Department of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, 6020, Austria., Wortmann SB; University Children's Hospital, Salzburger Landeskliniken and Paracelsus Medical University, Salzburg, 5020, Austria.; Amalia Children's Hospital, Department of Pediatrics, Pediatric Neurology, Nijmegen, The Netherlands., Nemati S; Kinder- und Jugendheilkunde, Krankenhaus St. Vinzenz Zams, Zams, 6511, Austria., Mayr JA; University Children's Hospital, Salzburger Landeskliniken and Paracelsus Medical University, Salzburg, 5020, Austria., Zschocke J; Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, 6020, Austria., Radlinger B; Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, 6020, Austria., Thedieck K; Department of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, 6020, Austria.; Department Metabolism, Senescence and Autophagy, Research Center One Health Ruhr, University Alliance Ruhr & University Hospital Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen, a partnership between German Cancer Research Center (DKFZ) and University Hospital Essen, Heidelberg, Germany.; Freiburg Materials Research Center (FMF), University Freiburg, Freiburg, Germany.; Laboratory of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Kremser L; Institute of Medical Biochemistry, Protein Core Facility, Medical University of Innsbruck, Innsbruck, Austria., Sarg B; Institute of Medical Biochemistry, Protein Core Facility, Medical University of Innsbruck, Innsbruck, Austria., Huber LA; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Farhan H; Institute of Pathophysiology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., de Araujo MEG; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria., Kaser S; Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, 6020, Austria., Scholl-Bürgi S; Department of Child and Adolescent Health, Division of Pediatrics I-Inherited Metabolic Disorders, Medical University of Innsbruck, Innsbruck, 6020, Austria., Karall D; Department of Child and Adolescent Health, Division of Pediatrics I-Inherited Metabolic Disorders, Medical University of Innsbruck, Innsbruck, 6020, Austria., Teis D; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria. david.teis@i-med.ac.at.; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria. david.teis@i-med.ac.at.
Source: The EMBO journal [EMBO J] 2025 Dec; Vol. 44 (23), pp. 7119-7153. Date of Electronic Publication: 2025 Oct 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence.
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  Data: <searchLink fieldCode="AU" term="%22Kahlhofer+J%22">Kahlhofer J</searchLink>; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Marchet+N%22">Marchet N</searchLink>; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Zubak+K%22">Zubak K</searchLink>; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Seifert+B%22">Seifert B</searchLink>; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Hotze+M%22">Hotze M</searchLink>; Department of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Egger-Hörschinger+AS%22">Egger-Hörschinger AS</searchLink>; Department of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Kucej+L%22">Kucej L</searchLink>; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Manzl+C%22">Manzl C</searchLink>; Institute of Neuropathology & Neuromolecular Pathology, Medical University of Innsbruck, 6020, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Weyer+Y%22">Weyer Y</searchLink>; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Weys+S%22">Weys S</searchLink>; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.; Institute of Science and Technology Austria (ISTA), Klosterneuburg, 3400, Austria.<br /><searchLink fieldCode="AU" term="%22Offterdinger+M%22">Offterdinger M</searchLink>; Institute of Systems Neuroscience, BioOptics core facility, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Herzog+S%22">Herzog S</searchLink>; Institute for Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Reiterer+V%22">Reiterer V</searchLink>; Institute of Pathophysiology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Volani+C%22">Volani C</searchLink>; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Kwiatkowski+M%22">Kwiatkowski M</searchLink>; Department of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Wortmann+SB%22">Wortmann SB</searchLink>; University Children's Hospital, Salzburger Landeskliniken and Paracelsus Medical University, Salzburg, 5020, Austria.; Amalia Children's Hospital, Department of Pediatrics, Pediatric Neurology, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nemati+S%22">Nemati S</searchLink>; Kinder- und Jugendheilkunde, Krankenhaus St. Vinzenz Zams, Zams, 6511, Austria.<br /><searchLink fieldCode="AU" term="%22Mayr+JA%22">Mayr JA</searchLink>; University Children's Hospital, Salzburger Landeskliniken and Paracelsus Medical University, Salzburg, 5020, Austria.<br /><searchLink fieldCode="AU" term="%22Zschocke+J%22">Zschocke J</searchLink>; Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Radlinger+B%22">Radlinger B</searchLink>; Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Thedieck+K%22">Thedieck K</searchLink>; Department of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, 6020, Austria.; Department Metabolism, Senescence and Autophagy, Research Center One Health Ruhr, University Alliance Ruhr & University Hospital Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen, a partnership between German Cancer Research Center (DKFZ) and University Hospital Essen, Heidelberg, Germany.; Freiburg Materials Research Center (FMF), University Freiburg, Freiburg, Germany.; Laboratory of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kremser+L%22">Kremser L</searchLink>; Institute of Medical Biochemistry, Protein Core Facility, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Sarg+B%22">Sarg B</searchLink>; Institute of Medical Biochemistry, Protein Core Facility, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Huber+LA%22">Huber LA</searchLink>; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Farhan+H%22">Farhan H</searchLink>; Institute of Pathophysiology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22de+Araujo+MEG%22">de Araujo MEG</searchLink>; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Kaser+S%22">Kaser S</searchLink>; Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Scholl-Bürgi+S%22">Scholl-Bürgi S</searchLink>; Department of Child and Adolescent Health, Division of Pediatrics I-Inherited Metabolic Disorders, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Karall+D%22">Karall D</searchLink>; Department of Child and Adolescent Health, Division of Pediatrics I-Inherited Metabolic Disorders, Medical University of Innsbruck, Innsbruck, 6020, Austria.<br /><searchLink fieldCode="AU" term="%22Teis+D%22">Teis D</searchLink>; Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria. david.teis@i-med.ac.at.; Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, 6020, Austria. david.teis@i-med.ac.at.
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