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Discovery of Pyrazole-Based Positron Emission Tomography Agent that Maps Histone Deacetylase 6 (HDAC6) in the Nonhuman Primate Brain.

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Title: Discovery of Pyrazole-Based Positron Emission Tomography Agent that Maps Histone Deacetylase 6 (HDAC6) in the Nonhuman Primate Brain.
Authors: Yamasaki T; National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan., Ohyabu N; Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan., Wakabayashi T; Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan., Ibáñez I; Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan., Iwanaga K; Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan., Yamamoto S; Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan., Hattori M; Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan., Sugita T; Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan., Terada M; Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan., Onishi T; Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan., Sato S; Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan., Kosugi Y; Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan., Takano A; Takeda Pharmaceutical Company Limited, Chuo-ku, Osaka 540-8645, Japan., McQuade P; Takeda Development Center Americas, Inc., Cambridge, Massachusetts 02142, United States., Maru T; Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa 251-0012, Japan., Inui N; Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa 251-0012, Japan., Fujinaga M; National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan., Mori W; National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan., Nagai Y; National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan., Seki C; National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan., Uchida S; National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan., Minamimoto T; National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan., Higuchi M; National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan., Fushimi M; Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan., Zhang MR; National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Nov 13; Vol. 68 (21), pp. 23375-23388. Date of Electronic Publication: 2025 Oct 20.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.5c02216