The combination of venetoclax with dimethyl fumarate synergistically induces apoptosis in AML cells by disrupting mitochondrial integrity through ROS accumulation.
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| Title: | The combination of venetoclax with dimethyl fumarate synergistically induces apoptosis in AML cells by disrupting mitochondrial integrity through ROS accumulation. |
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| Authors: | Kawaguchi SI; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Sato K; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. kazuya@jichi.ac.jp., Izawa J; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Takayama N; Center for Cytometry Research, Jichi Medical University, Tochigi, Japan., Hayakawa H; Center for Cytometry Research, Jichi Medical University, Tochigi, Japan., Tominaga K; Division of Structural Biochemistry, Department of Biochemistry, Jichi Medical University, Tochigi, Japan., Endo H; Division of Functional Biochemistry, Department of Biochemistry, Jichi Medical University, Tochigi, Japan., Kouki T; Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University, Tochigi, Japan., Ohno N; Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University, Tochigi, Japan., Kanda Y; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. |
| Source: | Cell death & disease [Cell Death Dis] 2025 Oct 21; Vol. 16 (1), pp. 750. Date of Electronic Publication: 2025 Oct 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-025-08040-x |
