The combination of venetoclax with dimethyl fumarate synergistically induces apoptosis in AML cells by disrupting mitochondrial integrity through ROS accumulation.
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| Title: | The combination of venetoclax with dimethyl fumarate synergistically induces apoptosis in AML cells by disrupting mitochondrial integrity through ROS accumulation. |
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| Authors: | Kawaguchi SI; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Sato K; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. kazuya@jichi.ac.jp., Izawa J; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Takayama N; Center for Cytometry Research, Jichi Medical University, Tochigi, Japan., Hayakawa H; Center for Cytometry Research, Jichi Medical University, Tochigi, Japan., Tominaga K; Division of Structural Biochemistry, Department of Biochemistry, Jichi Medical University, Tochigi, Japan., Endo H; Division of Functional Biochemistry, Department of Biochemistry, Jichi Medical University, Tochigi, Japan., Kouki T; Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University, Tochigi, Japan., Ohno N; Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University, Tochigi, Japan., Kanda Y; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. |
| Source: | Cell death & disease [Cell Death Dis] 2025 Oct 21; Vol. 16 (1), pp. 750. Date of Electronic Publication: 2025 Oct 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41120282 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The combination of venetoclax with dimethyl fumarate synergistically induces apoptosis in AML cells by disrupting mitochondrial integrity through ROS accumulation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Kawaguchi+SI%22">Kawaguchi SI</searchLink>; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+K%22">Sato K</searchLink>; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. kazuya@jichi.ac.jp.<br /><searchLink fieldCode="AU" term="%22Izawa+J%22">Izawa J</searchLink>; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Takayama+N%22">Takayama N</searchLink>; Center for Cytometry Research, Jichi Medical University, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Hayakawa+H%22">Hayakawa H</searchLink>; Center for Cytometry Research, Jichi Medical University, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Tominaga+K%22">Tominaga K</searchLink>; Division of Structural Biochemistry, Department of Biochemistry, Jichi Medical University, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Endo+H%22">Endo H</searchLink>; Division of Functional Biochemistry, Department of Biochemistry, Jichi Medical University, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Kouki+T%22">Kouki T</searchLink>; Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Ohno+N%22">Ohno N</searchLink>; Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Kanda+Y%22">Kanda Y</searchLink>; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2025 Oct 21; Vol. 16 (1), pp. 750. <i>Date of Electronic Publication: </i>2025 Oct 21. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41120282 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41419-025-08040-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 750 Titles: – TitleFull: The combination of venetoclax with dimethyl fumarate synergistically induces apoptosis in AML cells by disrupting mitochondrial integrity through ROS accumulation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kawaguchi SI – PersonEntity: Name: NameFull: Sato K – PersonEntity: Name: NameFull: Izawa J – PersonEntity: Name: NameFull: Takayama N – PersonEntity: Name: NameFull: Hayakawa H – PersonEntity: Name: NameFull: Tominaga K – PersonEntity: Name: NameFull: Endo H – PersonEntity: Name: NameFull: Kouki T – PersonEntity: Name: NameFull: Ohno N – PersonEntity: Name: NameFull: Kanda Y IsPartOfRelationships: – BibEntity: Dates: – D: 21 M: 10 Text: 2025 Oct 21 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2041-4889 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: Cell death & disease Type: main |
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