Modulating Chromophore Flexibility in GEVIs through Threonine-Based Molecular Switches Reveals an Influence of Membrane Curvature on Protein Activity.

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Title: Modulating Chromophore Flexibility in GEVIs through Threonine-Based Molecular Switches Reveals an Influence of Membrane Curvature on Protein Activity.
Authors: Leong LM; Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.; Department of Biological Science, Florida State University, Tallahassee, Florida 32306, United States., Shin SC; Technological Convergence Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea., Frankiv N; Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, The National University of Science and Technology, Seoul 02792, Republic of Korea., Rhee JK; Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea., Kim H; Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Biomedical Sciences and Pharmacology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea., Seong J; Department of Biomedical Sciences and Pharmacology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea., Woo J; Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea., Han K; Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, The National University of Science and Technology, Seoul 02792, Republic of Korea., Storace DA; Department of Biological Science, Florida State University, Tallahassee, Florida 32306, United States.; Program in Neuroscience, Florida State University, Tallahassee, Florida 32306, United States.; Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, United States., Baker BJ; Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, The National University of Science and Technology, Seoul 02792, Republic of Korea.
Source: ACS sensors [ACS Sens] 2025 Nov 28; Vol. 10 (11), pp. 8395-8410. Date of Electronic Publication: 2025 Oct 22.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101669031 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2379-3694 (Electronic) Linking ISSN: 23793694 NLM ISO Abbreviation: ACS Sens Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2379-3694
DOI:10.1021/acssensors.5c01748