Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease.

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Title: Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease.
Authors: Nguyen C; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Broersma EH; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Warden AS; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Mora C; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Han CZ; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Keulen Z; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Spann N; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Wang J; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Ramirez G; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Mak S; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Trescott S; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Khakpour M; School of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada., Johnson A; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Qureshi F; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., La Frano MR; Salk Institute for Biological Studies, La Jolla, CA, USA., Mohajeri K; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA., Talkowski ME; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA., Corradin O; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Tremblay MÈ; School of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada., Glass CK; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA. cglass@health.ucsd.edu., Coufal NG; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA. ncoufal@health.ucsd.edu.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA. ncoufal@health.ucsd.edu.
Source: Nature immunology [Nat Immunol] 2025 Nov; Vol. 26 (11), pp. 1989-2003. Date of Electronic Publication: 2025 Oct 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1529-2916
DOI:10.1038/s41590-025-02299-0