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Dimethoxybenzohomoadamantane-based soluble epoxide hydrolase inhibitors: in vivo efficacy in a murine model of chemotherapy-induced neuropathic pain.

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Title: Dimethoxybenzohomoadamantane-based soluble epoxide hydrolase inhibitors: in vivo efficacy in a murine model of chemotherapy-induced neuropathic pain.
Authors: Codony S; Laboratori de Química Farmacèutica, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain., Jora B; Laboratori de Química Farmacèutica, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain., Santos-Caballero M; Department of Pharmacology, Faculty of Medicine and Biomedical Research Center (Neurosciences Institute), University of Granada, Biosanitary Research Institute-ibs.GRANADA, Granada, Spain., Qiu Q; Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, London, UK., Calvó-Tusell C; Departament de Química and Institut de Química Computacional i Catàlisi (IQCC), Universitat de Girona, Girona, Spain., Escriche C; Laboratori de Química Farmacèutica, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain., Turcu AL; Laboratori de Química Farmacèutica, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain., Prischi F; Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, London, UK., Bartra C; Institute of Biomedical Research of Barcelona (IIBB), CSIC, Barcelona, Spain., Val C; Innopharma Drug Screening Platform/Biofarma Research Group, CIMUS Research Center, Pharmacology Department, School of Pharmacy, University of Santiago de Compostela (USC), Santiago de Compostela, Spain., Morisseau C; Department of Entomology and Nematology and Comprehensive Cancer Center, University of California, Davis, CA, USA., Pérez B; Department of Pharmacology, Therapeutics and Toxicology, Institute of Neurosciences, Autonomous University of Barcelona, Barcelona, Spain., Bertran-Mostazo A; Institute of Biomedicine of the University of Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.; Departament de Farmàcia i Tecnología Farmacèutica, i Fisicoquímica, Universitat de Barcelona, Barcelona, Spain., Osuna S; Departament de Química and Institut de Química Computacional i Catàlisi (IQCC), Universitat de Girona, Girona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain., Corpas R; Institute of Biomedical Research of Barcelona (IIBB), CSIC, Barcelona, Spain., Griñán-Ferré C; Pharmacology Section, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Neuroscience, University of Barcelona (NeuroUB), Barcelona, Spain.; Centro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Galdeano C; Institute of Biomedicine of the University of Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.; Departament de Farmàcia i Tecnología Farmacèutica, i Fisicoquímica, Universitat de Barcelona, Barcelona, Spain., Loza MI; Innopharma Drug Screening Platform/Biofarma Research Group, CIMUS Research Center, Pharmacology Department, School of Pharmacy, University of Santiago de Compostela (USC), Santiago de Compostela, Spain., Pallàs M; Pharmacology Section, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Neuroscience, University of Barcelona (NeuroUB), Barcelona, Spain.; Centro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Sanfeliu C; Institute of Biomedical Research of Barcelona (IIBB), CSIC, Barcelona, Spain., Hammock BD; Department of Entomology and Nematology and Comprehensive Cancer Center, University of California, Davis, CA, USA., Brea J; Innopharma Drug Screening Platform/Biofarma Research Group, CIMUS Research Center, Pharmacology Department, School of Pharmacy, University of Santiago de Compostela (USC), Santiago de Compostela, Spain., Feixas F; Departament de Química and Institut de Química Computacional i Catàlisi (IQCC), Universitat de Girona, Girona, Spain., Conte MR; Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, London, UK., Cobos EJ; Department of Pharmacology, Faculty of Medicine and Biomedical Research Center (Neurosciences Institute), University of Granada, Biosanitary Research Institute-ibs.GRANADA, Granada, Spain., Vázquez S; Laboratori de Química Farmacèutica, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2574990. Date of Electronic Publication: 2025 Oct 23.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1475-6374
DOI:10.1080/14756366.2025.2574990