Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface.
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| Title: | Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface. |
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| Authors: | Burendei B; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Kaplan JP; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.; Program in Neuroscience, University of Southern California, Los Angeles, CA, USA., Orellana GM; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA., Liman ER; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA. liman@usc.edu.; Program in Neuroscience, University of Southern California, Los Angeles, CA, USA. liman@usc.edu., Forli S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. forli@scripps.edu., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. andrew@scripps.edu. |
| Source: | Nature communications [Nat Commun] 2025 Oct 23; Vol. 16 (1), pp. 9362. Date of Electronic Publication: 2025 Oct 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-64392-0 |
