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Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface.

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Title: Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface.
Authors: Burendei B; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Kaplan JP; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.; Program in Neuroscience, University of Southern California, Los Angeles, CA, USA., Orellana GM; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA., Liman ER; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA. liman@usc.edu.; Program in Neuroscience, University of Southern California, Los Angeles, CA, USA. liman@usc.edu., Forli S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. forli@scripps.edu., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. andrew@scripps.edu.
Source: Nature communications [Nat Commun] 2025 Oct 23; Vol. 16 (1), pp. 9362. Date of Electronic Publication: 2025 Oct 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface.
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  Data: <searchLink fieldCode="AU" term="%22Burendei+B%22">Burendei B</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kaplan+JP%22">Kaplan JP</searchLink>; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.; Program in Neuroscience, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Orellana+GM%22">Orellana GM</searchLink>; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liman+ER%22">Liman ER</searchLink>; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA. liman@usc.edu.; Program in Neuroscience, University of Southern California, Los Angeles, CA, USA. liman@usc.edu.<br /><searchLink fieldCode="AU" term="%22Forli+S%22">Forli S</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. forli@scripps.edu.<br /><searchLink fieldCode="AU" term="%22Ward+AB%22">Ward AB</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. andrew@scripps.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Oct 23; Vol. 16 (1), pp. 9362. <i>Date of Electronic Publication: </i>2025 Oct 23.
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