Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses.

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Title: Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses.
Authors: Vasili E; University Medical Center Gottingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany., König A; University Medical Center Gottingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany., Al-Azzani M; University Medical Center Gottingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany., Bosbach C; University Medical Center Gottingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany.; Institute of Organic and Biomolecular Chemistry, Georg-August-University Göttingen, Göttingen, Germany., Gatzemeier LM; University Medical Center Gottingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany.; Institute of Organic and Biomolecular Chemistry, Georg-August-University Göttingen, Göttingen, Germany., Thom S; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Chegão A; iNOVA4Health, NOVA Medical School, NMS, Universidade NOVA de Lisboa, Lisboa, Portugal., Vicente Miranda H; iNOVA4Health, NOVA Medical School, NMS, Universidade NOVA de Lisboa, Lisboa, Portugal., Steinem C; Institute of Organic and Biomolecular Chemistry, Georg-August-University Göttingen, Göttingen, Germany., Erskine D; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Outeiro TF; University Medical Center Gottingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany. touteir@gwdg.de.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. touteir@gwdg.de.; Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. touteir@gwdg.de.; Scientific employee with an honorary contract at Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Göttingen, Germany. touteir@gwdg.de.
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2025 Oct 23; Vol. 11 (1), pp. 307. Date of Electronic Publication: 2025 Oct 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2373-8057
DOI:10.1038/s41531-025-01159-w