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HCB101: a novel potent ligand-trap Fc-fusion protein targeting the CD47-SIRPα pathway with high safety and preclinical efficacy for hematological and solid tumors.

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Title: HCB101: a novel potent ligand-trap Fc-fusion protein targeting the CD47-SIRPα pathway with high safety and preclinical efficacy for hematological and solid tumors.
Authors: Wang JT; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Tseng CL; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Teng HF; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Kuo PH; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Cheng YC; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Chen YJ; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Lu YH; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Wang CC; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Shen TK; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Wang HF; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Tsai PL; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Wu YC; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Ho CH; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Sun WT; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Li YC; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Lee YH; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Hung YJ; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Chen M; Department of Pathology, UT Southwestern Medical Center, 2330 Inwood Rd, Dallas, 75390, TX, USA., Li Z; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - James, 460 W 10th Avenue, Columbus, 43210, OH, USA., Juo ZS; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan., Zhai W; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan. Wenwu_Zhai@hanchorbio.com., Liu SS; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan. Scott_Liu@hanchorbio.com.
Source: Journal of hematology & oncology [J Hematol Oncol] 2025 Oct 23; Vol. 18 (1), pp. 87. Date of Electronic Publication: 2025 Oct 23.
Publication Type: Letter
Journal Info: Publisher: Biomed Central Country of Publication: England NLM ID: 101468937 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-8722 (Electronic) Linking ISSN: 17568722 NLM ISO Abbreviation: J Hematol Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Editorial & Opinion
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  Label: Title
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  Data: HCB101: a novel potent ligand-trap Fc-fusion protein targeting the CD47-SIRPα pathway with high safety and preclinical efficacy for hematological and solid tumors.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Wang+JT%22">Wang JT</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tseng+CL%22">Tseng CL</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Teng+HF%22">Teng HF</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kuo+PH%22">Kuo PH</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+YC%22">Cheng YC</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YJ%22">Chen YJ</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lu+YH%22">Lu YH</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+CC%22">Wang CC</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shen+TK%22">Shen TK</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+HF%22">Wang HF</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+PL%22">Tsai PL</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+YC%22">Wu YC</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ho+CH%22">Ho CH</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sun+WT%22">Sun WT</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+YC%22">Li YC</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+YH%22">Lee YH</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+YJ%22">Hung YJ</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; Department of Pathology, UT Southwestern Medical Center, 2330 Inwood Rd, Dallas, 75390, TX, USA.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - James, 460 W 10th Avenue, Columbus, 43210, OH, USA.<br /><searchLink fieldCode="AU" term="%22Juo+ZS%22">Juo ZS</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan.<br /><searchLink fieldCode="AU" term="%22Zhai+W%22">Zhai W</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan. Wenwu_Zhai@hanchorbio.com.<br /><searchLink fieldCode="AU" term="%22Liu+SS%22">Liu SS</searchLink>; HanchorBio Inc, No. 1, Sec. 1, Tiding Blvd. Neihu Dist, Taipei City, 114066, Taiwan. Scott_Liu@hanchorbio.com.
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  Data: <searchLink fieldCode="JN" term="%22101468937%22">Journal of hematology & oncology</searchLink> [J Hematol Oncol] 2025 Oct 23; Vol. 18 (1), pp. 87. <i>Date of Electronic Publication: </i>2025 Oct 23.
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  Data: Letter
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Biomed+Central%22">Biomed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101468937 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1756-8722 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217568722%22">17568722 </searchLink><i>NLM ISO Abbreviation: </i>J Hematol Oncol <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41131565
RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1186/s13045-025-01742-x
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        Text: English
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        StartPage: 87
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              Text: 2025 Oct 23
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