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Mechanobiologically-optimized non-resorbable artificial bone for patient-matched scaffold-guided bone regeneration.

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Title: Mechanobiologically-optimized non-resorbable artificial bone for patient-matched scaffold-guided bone regeneration.
Authors: Clark JR; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia. jonathan.clark@lh.org.au.; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia. jonathan.clark@lh.org.au.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia. jonathan.clark@lh.org.au.; Royal Prince Alfred Institute of Academic Surgery, Sydney Local Health District, Camperdown, NSW, Australia. jonathan.clark@lh.org.au.; Department of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Camperdown, NSW, Australia. jonathan.clark@lh.org.au., Al Maruf DSA; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia., Tomaskovic-Crook E; Arto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Intelligent Polymer Research Institute and Institute of Innovative Materials, Faculty of Engineering and Information Sciences, The University of Wollongong, Fairy Meadow, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia., Cheng K; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Royal Prince Alfred Institute of Academic Surgery, Sydney Local Health District, Camperdown, NSW, Australia., Lewin WT; Arto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.; Sarcoma and Surgical Research Centre, Chris O'Brien Lifehouse, Camperdown, NSW, Australia., Xin H; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia., Wan B; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Camperdown, NSW, Australia., Ren J; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; ARC Training Centre for Cells and Tissue Engineering Technologies, Central Analytical Research Facility, Research Infrastructure, Queensland University of Technology, Brisbane, QLD, Australia., Wu C; School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Camperdown, NSW, Australia., Kruse HV; Arto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Sarcoma and Surgical Research Centre, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; School of Physics, The University of Sydney, Camperdown, NSW, Australia., Lawrence DK; Australian National Fabrication Facility-Materials Node, AIIM Facility, The University of Wollongong, Wollongong, NSW, Australia., Wise I; Laboratory Animal Services, The University of Sydney, Camperdown, NSW, Australia., Gupta A; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia., Woodruff MA; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD, Australia., Rad MA; Arto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia., Leinkram D; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.; Department of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Camperdown, NSW, Australia., Manzie T; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.; Department of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Camperdown, NSW, Australia., Parthasarthi K; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.; Department of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Camperdown, NSW, Australia., Wykes J; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.; Department of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Camperdown, NSW, Australia., Low TH; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.; Department of Otolaryngology - Head & Neck Surgery, Faculty of Medicine and Health Sciences, Macquarie University, Macquarie Park, NSW, Australia., Howes D; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Sydney Dental School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia., Froggatt C; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Department of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Camperdown, NSW, Australia., Gupta R; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.; Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia., Wallace G; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; Intelligent Polymer Research Institute and Institute of Innovative Materials, Faculty of Engineering and Information Sciences, The University of Wollongong, Fairy Meadow, NSW, Australia., Li Q; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Camperdown, NSW, Australia.; Centre for Advanced Materials Technology, The University of Sydney, Darlington, NSW, Australia., McKenzie DR; Arto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Sarcoma and Surgical Research Centre, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; School of Physics, The University of Sydney, Camperdown, NSW, Australia., Crook JM; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia. jeremy.crook@lh.org.au.; Arto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Camperdown, NSW, Australia. jeremy.crook@lh.org.au.; Intelligent Polymer Research Institute and Institute of Innovative Materials, Faculty of Engineering and Information Sciences, The University of Wollongong, Fairy Meadow, NSW, Australia. jeremy.crook@lh.org.au.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia. jeremy.crook@lh.org.au.; Sarcoma and Surgical Research Centre, Chris O'Brien Lifehouse, Camperdown, NSW, Australia. jeremy.crook@lh.org.au.
Source: Nature communications [Nat Commun] 2025 Oct 24; Vol. 16 (1), pp. 9422. Date of Electronic Publication: 2025 Oct 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mechanobiologically-optimized non-resorbable artificial bone for patient-matched scaffold-guided bone regeneration.
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  Data: <searchLink fieldCode="AU" term="%22Clark+JR%22">Clark JR</searchLink>; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia. jonathan.clark@lh.org.au.; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia. jonathan.clark@lh.org.au.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia. jonathan.clark@lh.org.au.; Royal Prince Alfred Institute of Academic Surgery, Sydney Local Health District, Camperdown, NSW, Australia. jonathan.clark@lh.org.au.; Department of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Camperdown, NSW, Australia. jonathan.clark@lh.org.au.<br /><searchLink fieldCode="AU" term="%22Al+Maruf+DSA%22">Al Maruf DSA</searchLink>; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Tomaskovic-Crook+E%22">Tomaskovic-Crook E</searchLink>; Arto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Intelligent Polymer Research Institute and Institute of Innovative Materials, Faculty of Engineering and Information Sciences, The University of Wollongong, Fairy Meadow, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Cheng+K%22">Cheng K</searchLink>; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Royal Prince Alfred Institute of Academic Surgery, Sydney Local Health District, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Lewin+WT%22">Lewin WT</searchLink>; Arto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.; Sarcoma and Surgical Research Centre, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Xin+H%22">Xin H</searchLink>; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Wan+B%22">Wan B</searchLink>; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Ren+J%22">Ren J</searchLink>; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; ARC Training Centre for Cells and Tissue Engineering Technologies, Central Analytical Research Facility, Research Infrastructure, Queensland University of Technology, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Kruse+HV%22">Kruse HV</searchLink>; Arto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Sarcoma and Surgical Research Centre, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; School of Physics, The University of Sydney, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Lawrence+DK%22">Lawrence DK</searchLink>; Australian National Fabrication Facility-Materials Node, AIIM Facility, The University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Wise+I%22">Wise I</searchLink>; Laboratory Animal Services, The University of Sydney, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Gupta+A%22">Gupta A</searchLink>; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Woodruff+MA%22">Woodruff MA</searchLink>; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Rad+MA%22">Rad MA</searchLink>; Arto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Leinkram+D%22">Leinkram D</searchLink>; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.; Department of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Manzie+T%22">Manzie T</searchLink>; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.; Department of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Parthasarthi+K%22">Parthasarthi K</searchLink>; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.; Department of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Wykes+J%22">Wykes J</searchLink>; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.; Department of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Low+TH%22">Low TH</searchLink>; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.; Department of Otolaryngology - Head & Neck Surgery, Faculty of Medicine and Health Sciences, Macquarie University, Macquarie Park, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Howes+D%22">Howes D</searchLink>; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Sydney Dental School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Froggatt+C%22">Froggatt C</searchLink>; Integrated Prosthetics and Reconstruction, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Department of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Gupta+R%22">Gupta R</searchLink>; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.; Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Wallace+G%22">Wallace G</searchLink>; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; Intelligent Polymer Research Institute and Institute of Innovative Materials, Faculty of Engineering and Information Sciences, The University of Wollongong, Fairy Meadow, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia.; School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Camperdown, NSW, Australia.; Centre for Advanced Materials Technology, The University of Sydney, Darlington, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22McKenzie+DR%22">McKenzie DR</searchLink>; Arto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Sarcoma and Surgical Research Centre, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; School of Physics, The University of Sydney, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Crook+JM%22">Crook JM</searchLink>; NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia. jeremy.crook@lh.org.au.; Arto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Camperdown, NSW, Australia. jeremy.crook@lh.org.au.; Intelligent Polymer Research Institute and Institute of Innovative Materials, Faculty of Engineering and Information Sciences, The University of Wollongong, Fairy Meadow, NSW, Australia. jeremy.crook@lh.org.au.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia. jeremy.crook@lh.org.au.; Sarcoma and Surgical Research Centre, Chris O'Brien Lifehouse, Camperdown, NSW, Australia. jeremy.crook@lh.org.au.
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