Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment.
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| Title: | Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment. |
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| Authors: | Demir F; Department of Biomedicine, Aarhus University, Aarhus, Denmark. fatih.demir@biomed.au.dk., Kovalenko E; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Lassé M; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Svenningsen EB; Department of Chemistry, Aarhus University, Aarhus, Denmark., Bernth Jensen JM; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark., Billing AM; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Groeneveld K; Department of Internal Medicine III, Experimental Nephrology Group, University Hospital Jena, Jena, Germany., Hutzfeldt A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Nilges L; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Guerra JPL; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Pietrzak-Lichwa KJ; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Tan Y; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Colby E; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Hansen AG; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Kurmasheva N; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Olagnier D; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Choi D; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Richter MM; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Laufer SD; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Braun F; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany.; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Johnson SA; National Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK., Krüger M; Cologne Excellence Cluster Cellular Stress Response in Aging-Associated Diseases (CECAD), and Faculty of Mathematics and Natural Sciences, Institute of Genetics, University of Cologne, Cologne, Germany., Huber TB; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Hoxha E; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Steinmetz OM; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Mrowka R; Department of Internal Medicine III, Experimental Nephrology Group, University Hospital Jena, Jena, Germany.; Thuringian Innovation Center for Medical Technology Solutions ThIMEDOP, University Hospital Jena, Jena, Germany., Melderis S; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Saleem MA; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Poulsen TB; Department of Chemistry, Aarhus University, Aarhus, Denmark., Andersen GR; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Thiel S; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Troldborg A; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark., Rinschen MM; Department of Biomedicine, Aarhus University, Aarhus, Denmark. m.rinschen@uke.de.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. m.rinschen@uke.de.; Hamburg Center for Kidney Health, Hamburg, Germany. m.rinschen@uke.de.; National Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK. m.rinschen@uke.de. |
| Source: | The EMBO journal [EMBO J] 2025 Dec; Vol. 44 (24), pp. 7721-7758. Date of Electronic Publication: 2025 Oct 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1460-2075 |
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| DOI: | 10.1038/s44318-025-00598-8 |
