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Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment.

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Title: Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment.
Authors: Demir F; Department of Biomedicine, Aarhus University, Aarhus, Denmark. fatih.demir@biomed.au.dk., Kovalenko E; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Lassé M; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Svenningsen EB; Department of Chemistry, Aarhus University, Aarhus, Denmark., Bernth Jensen JM; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark., Billing AM; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Groeneveld K; Department of Internal Medicine III, Experimental Nephrology Group, University Hospital Jena, Jena, Germany., Hutzfeldt A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Nilges L; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Guerra JPL; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Pietrzak-Lichwa KJ; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Tan Y; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Colby E; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Hansen AG; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Kurmasheva N; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Olagnier D; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Choi D; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Richter MM; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Laufer SD; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Braun F; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany.; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Johnson SA; National Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK., Krüger M; Cologne Excellence Cluster Cellular Stress Response in Aging-Associated Diseases (CECAD), and Faculty of Mathematics and Natural Sciences, Institute of Genetics, University of Cologne, Cologne, Germany., Huber TB; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Hoxha E; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Steinmetz OM; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Mrowka R; Department of Internal Medicine III, Experimental Nephrology Group, University Hospital Jena, Jena, Germany.; Thuringian Innovation Center for Medical Technology Solutions ThIMEDOP, University Hospital Jena, Jena, Germany., Melderis S; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany., Saleem MA; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Poulsen TB; Department of Chemistry, Aarhus University, Aarhus, Denmark., Andersen GR; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Thiel S; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Troldborg A; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark., Rinschen MM; Department of Biomedicine, Aarhus University, Aarhus, Denmark. m.rinschen@uke.de.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. m.rinschen@uke.de.; Hamburg Center for Kidney Health, Hamburg, Germany. m.rinschen@uke.de.; National Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK. m.rinschen@uke.de.
Source: The EMBO journal [EMBO J] 2025 Dec; Vol. 44 (24), pp. 7721-7758. Date of Electronic Publication: 2025 Oct 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment.
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  Data: <searchLink fieldCode="AU" term="%22Demir+F%22">Demir F</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark. fatih.demir@biomed.au.dk.<br /><searchLink fieldCode="AU" term="%22Kovalenko+E%22">Kovalenko E</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Lassé+M%22">Lassé M</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Svenningsen+EB%22">Svenningsen EB</searchLink>; Department of Chemistry, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Bernth+Jensen+JM%22">Bernth Jensen JM</searchLink>; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Billing+AM%22">Billing AM</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Groeneveld+K%22">Groeneveld K</searchLink>; Department of Internal Medicine III, Experimental Nephrology Group, University Hospital Jena, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Hutzfeldt+A%22">Hutzfeldt A</searchLink>; III. 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Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Guerra+JPL%22">Guerra JPL</searchLink>; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Pietrzak-Lichwa+KJ%22">Pietrzak-Lichwa KJ</searchLink>; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Tan+Y%22">Tan Y</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Colby+E%22">Colby E</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Hansen+AG%22">Hansen AG</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Kurmasheva+N%22">Kurmasheva N</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Olagnier+D%22">Olagnier D</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Choi+D%22">Choi D</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Richter+MM%22">Richter MM</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Laufer+SD%22">Laufer SD</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Braun+F%22">Braun F</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany.; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Johnson+SA%22">Johnson SA</searchLink>; National Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Krüger+M%22">Krüger M</searchLink>; Cologne Excellence Cluster Cellular Stress Response in Aging-Associated Diseases (CECAD), and Faculty of Mathematics and Natural Sciences, Institute of Genetics, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Huber+TB%22">Huber TB</searchLink>; III. 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Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Saleem+MA%22">Saleem MA</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Poulsen+TB%22">Poulsen TB</searchLink>; Department of Chemistry, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+GR%22">Andersen GR</searchLink>; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Thiel+S%22">Thiel S</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Troldborg+A%22">Troldborg A</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Rinschen+MM%22">Rinschen MM</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark. m.rinschen@uke.de.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. m.rinschen@uke.de.; Hamburg Center for Kidney Health, Hamburg, Germany. m.rinschen@uke.de.; National Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK. m.rinschen@uke.de.
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