Rescue of imprinted genes by epigenome editing in human cellular models of Prader-Willi syndrome.
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| Title: | Rescue of imprinted genes by epigenome editing in human cellular models of Prader-Willi syndrome. |
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| Authors: | Nemoto A; Department of Physiology, Keio University School of Medicine, Tokyo, Japan.; Keio University Regenerative Medicine Research Center, Kawasaki, Japan.; Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo, Japan., Imaizumi K; Department of Physiology, Keio University School of Medicine, Tokyo, Japan.; Keio University Regenerative Medicine Research Center, Kawasaki, Japan.; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Miya F; Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan., Hiroi Y; Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo, Japan., Yamada M; Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan., Ideno H; Department of Physiology, Keio University School of Medicine, Tokyo, Japan., Saitoh S; Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Kosaki K; Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan., Okuno H; Department of Physiology, Keio University School of Medicine, Tokyo, Japan. okuno.hironobu.6v@tokyo-med.ac.jp.; Keio University Regenerative Medicine Research Center, Kawasaki, Japan. okuno.hironobu.6v@tokyo-med.ac.jp.; Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo, Japan. okuno.hironobu.6v@tokyo-med.ac.jp.; Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan. okuno.hironobu.6v@tokyo-med.ac.jp., Okano H; Department of Physiology, Keio University School of Medicine, Tokyo, Japan. hidokano@keio.jp.; Keio University Regenerative Medicine Research Center, Kawasaki, Japan. hidokano@keio.jp. |
| Source: | Nature communications [Nat Commun] 2025 Oct 28; Vol. 16 (1), pp. 9442. Date of Electronic Publication: 2025 Oct 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-64932-8 |
