Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity.

Saved in:
Bibliographic Details
Title: Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity.
Authors: Sanchez-Garcia MA; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Sadiku P; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Ortmann BM; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Department of Medicine, University of Cambridge, Cambridge, UK., Wit N; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Department of Medicine, University of Cambridge, Cambridge, UK., Negishi Y; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Cell Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Coelho P; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Zhang A; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Pednekar C; CRUK Scotland Centre, IGC, University of Edinburgh, Edinburgh, UK., Howden AJM; Division of Cell Signalling and Immunology, University of Dundee, Dundee, UK., Griffith DM; The Usher Institute, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK., Seear R; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Department of Medicine, University of Cambridge, Cambridge, UK., Kindrick JD; NDM Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Mengede J; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Cell Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Cooper G; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Morrison T; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Watts ER; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Shimeld BT; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Reyes L; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Mirchandani AS; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Arienti S; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Xu X; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Thomson A; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Brenes AJ; Division of Cell Signalling and Immunology, University of Dundee, Dundee, UK.; Centre for Gene Regulation and Expression, University of Dundee, Dundee, UK., Turton HA; Division of Clinical Medicine, University of Sheffield, Sheffield, UK., Dowey R; Division of Clinical Medicine, University of Sheffield, Sheffield, UK., Hull RC; Division of Clinical Medicine, University of Sheffield, Sheffield, UK., Davidson-Smith H; MRC Human Genetics Unit, MRC IGC, University of Edinburgh, Edinburgh, UK., McLaren A; NHS Lothian, Respiratory Medicine, Edinburgh, UK., Deans A; NHS Lothian, Respiratory Medicine, Edinburgh, UK., Choudhury G; NHS Lothian, Respiratory Medicine, Edinburgh, UK., Doverman K; Edinburgh Critical Care Research Group, NHS Lothian, Royal Infirmary of Edinburgh, Edinburgh, UK., Hope D; Edinburgh Critical Care Research Group, NHS Lothian, Royal Infirmary of Edinburgh, Edinburgh, UK., Vick O; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Altitude Physiology Expeditions (APEX), Sheffield, UK., Woodhead A; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Altitude Physiology Expeditions (APEX), Sheffield, UK., Petrie I; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Altitude Physiology Expeditions (APEX), Sheffield, UK., Green S; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Altitude Physiology Expeditions (APEX), Sheffield, UK., Rzechorzek NM; Altitude Physiology Expeditions (APEX), Sheffield, UK.; MRC Laboratory of Molecular Biology, Cambridge, UK.; Department of Engineering, University of Cambridge, Cambridge, UK., Turtle L; Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; Tropical and Infectious Disease Unit, Liverpool University Hospitals NHS Foundation Trust (member of Liverpool Health Partners), Liverpool, UK., Openshaw PJM; Respiratory Infection Section, National Heart and Lung Institute, Imperial College London, London, UK., Semple MG; Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; Respiratory Department, Liverpool Institute of Child Health and Wellbeing, Alder Hey Children's Hospital NHS Foundation Trust, Liverpool, UK., Sproul D; MRC Human Genetics Unit and CRUK Edinburgh Centre, MRC IGC, University of Edinburgh, Edinburgh, UK., Baillie JK; The Roslin Institute, University of Edinburgh, Edinburgh, UK., Thompson AAR; Division of Clinical Medicine, University of Sheffield, Sheffield, UK., Mole DR; NDM Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, UK., von Kriegsheim A; CRUK Scotland Centre, IGC, University of Edinburgh, Edinburgh, UK., Whyte MKB; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Mhlanga MM; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Cell Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Nathan JA; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Department of Medicine, University of Cambridge, Cambridge, UK., Walmsley SR; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK. sarah.walmsley@ed.ac.uk.
Corporate Authors: PHOSP-COVID Study Collaborative Group
Source: Nature immunology [Nat Immunol] 2025 Nov; Vol. 26 (11), pp. 1903-1915. Date of Electronic Publication: 2025 Oct 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1529-2916
DOI:10.1038/s41590-025-02301-9