Allosteric inhibition of JAK2 with lysine-reactive compounds that bind the pseudokinase domain.

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Bibliographic Details
Title: Allosteric inhibition of JAK2 with lysine-reactive compounds that bind the pseudokinase domain.
Authors: Primi MC; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02215, United States., Tavares MT; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02215, United States., Hatcher JM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02215, United States., Kang H; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States., Kresina TAC; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States., Chakraborty S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02215, United States., Leroy E; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02215, United States., Schmoker AM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02215, United States., Jeon H; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02215, United States., Weisberg EL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States; Department of Medicine, Harvard Medical School, Boston, MA, 02215, United States., Akatsu T; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States., Griffin JD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States; Department of Medicine, Harvard Medical School, Boston, MA, 02215, United States., Scott DA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02215, United States., Eck MJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02215, United States. Electronic address: michael_eck@dfci.harvard.edu.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Jan 15; Vol. 302 (Pt 1), pp. 118274. Date of Electronic Publication: 2025 Oct 21.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1768-3254
DOI:10.1016/j.ejmech.2025.118274