Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model.

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Title: Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model.
Authors: Steczina S; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA., Mohran S; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA., Childers MC; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA., McMillen TS; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, USA., Naim A; School of Natural Sciences, University of Kent, Canterbury, UK., Pilagov M; School of Natural Sciences, University of Kent, Canterbury, UK., Dente M; Department of Experimental and Clinical Medicine, Division of Physiology, University of Florence, Italy., Kooiker KB; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA., Mandrycky C; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA., Tawde K; Department of Biology, University of Washington, Seattle, WA, USA., Hesson J; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA., Zhao J; College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China., Mathieu J; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA., Pioner JM; Department of Biology, University of Florence, Florence, Italy., Geeves MA; School of Natural Sciences, University of Kent, Canterbury, UK., Ma W; BioCAT, Department of Biology, Illinois Institute of Technology, Chicago, IL, USA; Center for Synchrotron Radiation Research and Instrumentation, Illinois Institute of Technology, Chicago, IL, USA., Moussavi-Harami F; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA., Kad NM; School of Natural Sciences, University of Kent, Canterbury, UK., Regnier M; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA. Electronic address: mregnier@uw.edu.
Source: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2025 Dec; Vol. 209, pp. 143-160. Date of Electronic Publication: 2025 Oct 28.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 0262322 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8584 (Electronic) Linking ISSN: 00222828 NLM ISO Abbreviation: J Mol Cell Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1095-8584
DOI:10.1016/j.yjmcc.2025.10.008