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Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model.

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Title: Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model.
Authors: Steczina S; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA., Mohran S; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA., Childers MC; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA., McMillen TS; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, USA., Naim A; School of Natural Sciences, University of Kent, Canterbury, UK., Pilagov M; School of Natural Sciences, University of Kent, Canterbury, UK., Dente M; Department of Experimental and Clinical Medicine, Division of Physiology, University of Florence, Italy., Kooiker KB; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA., Mandrycky C; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA., Tawde K; Department of Biology, University of Washington, Seattle, WA, USA., Hesson J; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA., Zhao J; College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China., Mathieu J; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA., Pioner JM; Department of Biology, University of Florence, Florence, Italy., Geeves MA; School of Natural Sciences, University of Kent, Canterbury, UK., Ma W; BioCAT, Department of Biology, Illinois Institute of Technology, Chicago, IL, USA; Center for Synchrotron Radiation Research and Instrumentation, Illinois Institute of Technology, Chicago, IL, USA., Moussavi-Harami F; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA., Kad NM; School of Natural Sciences, University of Kent, Canterbury, UK., Regnier M; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA. Electronic address: mregnier@uw.edu.
Source: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2025 Dec; Vol. 209, pp. 143-160. Date of Electronic Publication: 2025 Oct 28.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 0262322 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8584 (Electronic) Linking ISSN: 00222828 NLM ISO Abbreviation: J Mol Cell Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model.
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  Data: <searchLink fieldCode="AU" term="%22Steczina+S%22">Steczina S</searchLink>; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Mohran+S%22">Mohran S</searchLink>; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Childers+MC%22">Childers MC</searchLink>; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22McMillen+TS%22">McMillen TS</searchLink>; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Naim+A%22">Naim A</searchLink>; School of Natural Sciences, University of Kent, Canterbury, UK.<br /><searchLink fieldCode="AU" term="%22Pilagov+M%22">Pilagov M</searchLink>; School of Natural Sciences, University of Kent, Canterbury, UK.<br /><searchLink fieldCode="AU" term="%22Dente+M%22">Dente M</searchLink>; Department of Experimental and Clinical Medicine, Division of Physiology, University of Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Kooiker+KB%22">Kooiker KB</searchLink>; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Mandrycky+C%22">Mandrycky C</searchLink>; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Tawde+K%22">Tawde K</searchLink>; Department of Biology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Hesson+J%22">Hesson J</searchLink>; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Mathieu+J%22">Mathieu J</searchLink>; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Pioner+JM%22">Pioner JM</searchLink>; Department of Biology, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Geeves+MA%22">Geeves MA</searchLink>; School of Natural Sciences, University of Kent, Canterbury, UK.<br /><searchLink fieldCode="AU" term="%22Ma+W%22">Ma W</searchLink>; BioCAT, Department of Biology, Illinois Institute of Technology, Chicago, IL, USA; Center for Synchrotron Radiation Research and Instrumentation, Illinois Institute of Technology, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Moussavi-Harami+F%22">Moussavi-Harami F</searchLink>; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kad+NM%22">Kad NM</searchLink>; School of Natural Sciences, University of Kent, Canterbury, UK.<br /><searchLink fieldCode="AU" term="%22Regnier+M%22">Regnier M</searchLink>; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Translational Muscle Research, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA. Electronic address: mregnier@uw.edu.
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  Data: <searchLink fieldCode="JN" term="%220262322%22">Journal of molecular and cellular cardiology</searchLink> [J Mol Cell Cardiol] 2025 Dec; Vol. 209, pp. 143-160. <i>Date of Electronic Publication: </i>2025 Oct 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0262322 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-8584 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222828%22">00222828 </searchLink><i>NLM ISO Abbreviation: </i>J Mol Cell Cardiol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.yjmcc.2025.10.008
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        Text: English
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              Text: 2025 Dec
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