Long-term changes in hepatic reserve and prognosis after direct-acting antiviral treatment in patients with hepatitis C virus-related decompensated cirrhosis: a five-year follow-up study of a Japanese phase 3 trial.

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Title: Long-term changes in hepatic reserve and prognosis after direct-acting antiviral treatment in patients with hepatitis C virus-related decompensated cirrhosis: a five-year follow-up study of a Japanese phase 3 trial.
Authors: Tahata Y; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Hikita H; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Takaki A; Department of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan., Kurosaki M; Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan., Matsuura K; Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Yatsuhashi H; Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan., Kuroda H; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan., Ueno Y; Department of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, Japan., Maekawa S; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan., Nakamura M; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan., Sakamori R; National Hospital Organization Osaka National Hospital, Osaka, Osaka, Japan., Kodama T; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Takehara T; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. takehara@gh.med.osaka-u.ac.jp.
Source: Journal of gastroenterology [J Gastroenterol] 2026 Mar; Vol. 61 (3), pp. 302-313. Date of Electronic Publication: 2025 Oct 30.
Publication Type: Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial
Journal Info: Publisher: Springer International Country of Publication: Japan NLM ID: 9430794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-5922 (Electronic) Linking ISSN: 09441174 NLM ISO Abbreviation: J Gastroenterol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1435-5922
DOI:10.1007/s00535-025-02312-1