Long-term changes in hepatic reserve and prognosis after direct-acting antiviral treatment in patients with hepatitis C virus-related decompensated cirrhosis: a five-year follow-up study of a Japanese phase 3 trial.

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Title: Long-term changes in hepatic reserve and prognosis after direct-acting antiviral treatment in patients with hepatitis C virus-related decompensated cirrhosis: a five-year follow-up study of a Japanese phase 3 trial.
Authors: Tahata Y; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Hikita H; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Takaki A; Department of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan., Kurosaki M; Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan., Matsuura K; Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Yatsuhashi H; Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan., Kuroda H; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan., Ueno Y; Department of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, Japan., Maekawa S; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan., Nakamura M; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan., Sakamori R; National Hospital Organization Osaka National Hospital, Osaka, Osaka, Japan., Kodama T; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Takehara T; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. takehara@gh.med.osaka-u.ac.jp.
Source: Journal of gastroenterology [J Gastroenterol] 2026 Mar; Vol. 61 (3), pp. 302-313. Date of Electronic Publication: 2025 Oct 30.
Publication Type: Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial
Journal Info: Publisher: Springer International Country of Publication: Japan NLM ID: 9430794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-5922 (Electronic) Linking ISSN: 09441174 NLM ISO Abbreviation: J Gastroenterol Subsets: MEDLINE
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  Data: Long-term changes in hepatic reserve and prognosis after direct-acting antiviral treatment in patients with hepatitis C virus-related decompensated cirrhosis: a five-year follow-up study of a Japanese phase 3 trial.
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  Data: <searchLink fieldCode="AU" term="%22Tahata+Y%22">Tahata Y</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Hikita+H%22">Hikita H</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Takaki+A%22">Takaki A</searchLink>; Department of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Kurosaki+M%22">Kurosaki M</searchLink>; Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuura+K%22">Matsuura K</searchLink>; Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Yatsuhashi+H%22">Yatsuhashi H</searchLink>; Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Kuroda+H%22">Kuroda H</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan.<br /><searchLink fieldCode="AU" term="%22Ueno+Y%22">Ueno Y</searchLink>; Department of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, Japan.<br /><searchLink fieldCode="AU" term="%22Maekawa+S%22">Maekawa S</searchLink>; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.<br /><searchLink fieldCode="AU" term="%22Nakamura+M%22">Nakamura M</searchLink>; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Sakamori+R%22">Sakamori R</searchLink>; National Hospital Organization Osaka National Hospital, Osaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kodama+T%22">Kodama T</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Takehara+T%22">Takehara T</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. takehara@gh.med.osaka-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%229430794%22">Journal of gastroenterology</searchLink> [J Gastroenterol] 2026 Mar; Vol. 61 (3), pp. 302-313. <i>Date of Electronic Publication: </i>2025 Oct 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International%22">Springer International </searchLink><i>Country of Publication: </i>Japan <i>NLM ID: </i>9430794 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1435-5922 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209441174%22">09441174 </searchLink><i>NLM ISO Abbreviation: </i>J Gastroenterol <i>Subsets: </i>MEDLINE
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