Prostate cancer in situ autovaccination with the intratumoral viral mimic poly-ICLC: Modulating the cold tumor microenvironment.

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Title: Prostate cancer in situ autovaccination with the intratumoral viral mimic poly-ICLC: Modulating the cold tumor microenvironment.
Authors: Nair SS; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: sujit.nair@mountsinai.org., Chakravarty D; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Balan S; Department of Hematology and Oncology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Hakansson A; Veracyte, Inc., South San Francisco, CA 94080, USA., Duval M; Double Strand, Acton, MA 01720, USA., Davicioni E; Veracyte, Inc., South San Francisco, CA 94080, USA., Liu Y; Veracyte, Inc., South San Francisco, CA 94080, USA., Bhardwaj S; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Thin TH; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Garcia-Barros M; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Haines K; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Al Shaarani M; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pathology and Laboratory Medicine, UT Health Houston, Houston, TX 77030, USA., Weil R; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Meseck M; Vaccine and Cell Therapy Laboratory and Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ratnani P; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Fatterpekar M; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Gonzalez-Gugel E; Department of Hematology and Oncology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Farkas A; Department of Hematology and Oncology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Wagaskar V; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Jambor I; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Schlussel K; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Pasat-Karasik C; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Bhatt K; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Dovey Z; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Pedraza A; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Gupta A; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Lundon D; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Peros A; Department of Hematology and Oncology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Parekh S; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Davenport L; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Zhang X; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Gupta R; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Robison M; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Knauer C; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ellis E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Rykunov D; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Reva B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Padanilam B; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Galsky MD; Department of Hematology and Oncology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Brody R; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Menon M; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Salazar AM; Oncovir, Inc., Winchester, VA 22601, USA., Bhardwaj N; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Hematology and Oncology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Vaccine and Cell Therapy Laboratory and Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: nina.bhardwaj@mountsinai.org., Tewari AK; Department of Urology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: ash.tewari@mountsinai.org.
Source: Med (New York, N.Y.) [Med] 2025 Dec 12; Vol. 6 (12), pp. 100879. Date of Electronic Publication: 2025 Oct 30.
Publication Type: Journal Article; Clinical Trial, Phase I; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101769215 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-6340 (Electronic) Linking ISSN: 26666340 NLM ISO Abbreviation: Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-6340
DOI:10.1016/j.medj.2025.100879