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Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.

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Title: Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.
Authors: Enzan N; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Miyazawa K; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Koyama S; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Kurosawa R; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Ieki H; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Yoshida H; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Takechi F; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Pediatrics, Graduate School of Medical and Pharmaceutical Sciences, Chiba University, Chiba, Japan., Fukuyama M; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Osako R; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Cardiovascular Medicine, Saga University, Saga, Japan., Tomizuka K; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Liu X; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Ozaki K; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan., Onouchi Y; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Public Health, Chiba University Graduate School of Medicine, Chiba, Japan., Matsuda K; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Momozawa Y; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Aburatani H; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Kamatani Y; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Yamaguchi T; Department of Cardiovascular Medicine, Saga University, Saga, Japan., Akazawa H; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Node K; Department of Cardiovascular Medicine, Saga University, Saga, Japan., Ellinor PT; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Heart and Vascular Institute, Mass General Brigham, Boston, MA, USA., Levin MG; Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA., Damrauer SM; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Institute of Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Voight BF; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Institute of Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Joseph J; Veterans Affairs Providence Healthcare System, Providence, RI, USA.; Brown University, Providence, RI, USA., Sun YV; VA Atlanta Health Care System, Decatur, GA, USA.; Emory University Rollins School of Public Health, Atlanta, GA, USA., Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Ninomiya T; Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Itoshima, Japan., Komuro I; Department of Frontier Cardiovascular Science, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. komuro-tky@umin.ac.jp.; International University of Health and Welfare, Tokyo, Japan. komuro-tky@umin.ac.jp., Ito K; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. kaoru.ito@chiba-u.jp.; Department of Advanced Biomedical Data Science, Graduate School of Medicine, Chiba University, Chiba, Japan. kaoru.ito@chiba-u.jp.
Corporate Authors: BioBank Japan Project
Source: Nature communications [Nat Commun] 2025 Nov 03; Vol. 16 (1), pp. 9680. Date of Electronic Publication: 2025 Nov 03.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-64659-6