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Mitochondrial damage drives T-cell immunometabolic paralysis after major surgery.

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Title: Mitochondrial damage drives T-cell immunometabolic paralysis after major surgery.
Authors: Hirschberger S; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany., Müller MB; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany., Mascolo H; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany., Seitz M; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany., Nibler S; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany., Effinger D; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany., Lu K; Department of Cardiac Surgery, LMU University Hospital, LMU, Munich, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Büch J; Department of Cardiac Surgery, LMU University Hospital, LMU, Munich, Germany., Bender M; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany., Kammerer T; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany., Peterß S; Department of Cardiac Surgery, LMU University Hospital, LMU, Munich, Germany., Kleigrewe K; Bavarian Center for Biomolecular Mass Spectrometry, TUM School of Life Sciences, Technical University of Munich, Freising, Germany., Abele M; Bavarian Center for Biomolecular Mass Spectrometry, TUM School of Life Sciences, Technical University of Munich, Freising, Germany., Barth T; Protein Analysis Unit, BioMedical Center, Faculty of Medicine, LMU, Martinsried, Germany., Kushnir O; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany., Imhof A; Protein Analysis Unit, BioMedical Center, Faculty of Medicine, LMU, Martinsried, Germany., Dietzel S; Core Facility Bioimaging and Walter Brendel Center of Experimental Medicine, Biomedical Center, LMU, Munich, Germany.; Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Center for Experimental Medicine, LMU, Munich, Germany., Wegener B; Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, LMU University Hospital, LMU, Munich, Germany., Sowa R; Department of Anesthesiology and Intensive Care Medicine, University Medical Center Goettingen, Goettingen, Germany., Vogel F; Artemed Hospital Munich South, Munich, Germany., Lamm P; Artemed Hospital Munich South, Munich, Germany., Tomasi R; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany., Unger K; Department of Radiotherapy and Radiooncology, LMU University Hospital, LMU, Munich, Germany., Sperandio M; Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Center for Experimental Medicine, LMU, Munich, Germany., Kilger E; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany., Kreth S; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany. simone.kreth@med.uni-muenchen.de.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany. simone.kreth@med.uni-muenchen.de., Hübner M; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany.
Source: EMBO molecular medicine [EMBO Mol Med] 2025 Dec; Vol. 17 (12), pp. 3329-3354. Date of Electronic Publication: 2025 Nov 03.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
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  Data: Mitochondrial damage drives T-cell immunometabolic paralysis after major surgery.
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  Data: <searchLink fieldCode="AU" term="%22Hirschberger+S%22">Hirschberger S</searchLink>; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+MB%22">Müller MB</searchLink>; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Mascolo+H%22">Mascolo H</searchLink>; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Seitz+M%22">Seitz M</searchLink>; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Nibler+S%22">Nibler S</searchLink>; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Effinger+D%22">Effinger D</searchLink>; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lu+K%22">Lu K</searchLink>; Department of Cardiac Surgery, LMU University Hospital, LMU, Munich, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Büch+J%22">Büch J</searchLink>; Department of Cardiac Surgery, LMU University Hospital, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bender+M%22">Bender M</searchLink>; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kammerer+T%22">Kammerer T</searchLink>; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Peterß+S%22">Peterß S</searchLink>; Department of Cardiac Surgery, LMU University Hospital, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kleigrewe+K%22">Kleigrewe K</searchLink>; Bavarian Center for Biomolecular Mass Spectrometry, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Abele+M%22">Abele M</searchLink>; Bavarian Center for Biomolecular Mass Spectrometry, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Barth+T%22">Barth T</searchLink>; Protein Analysis Unit, BioMedical Center, Faculty of Medicine, LMU, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Kushnir+O%22">Kushnir O</searchLink>; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Imhof+A%22">Imhof A</searchLink>; Protein Analysis Unit, BioMedical Center, Faculty of Medicine, LMU, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Dietzel+S%22">Dietzel S</searchLink>; Core Facility Bioimaging and Walter Brendel Center of Experimental Medicine, Biomedical Center, LMU, Munich, Germany.; Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Center for Experimental Medicine, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wegener+B%22">Wegener B</searchLink>; Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, LMU University Hospital, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Sowa+R%22">Sowa R</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University Medical Center Goettingen, Goettingen, Germany.<br /><searchLink fieldCode="AU" term="%22Vogel+F%22">Vogel F</searchLink>; Artemed Hospital Munich South, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lamm+P%22">Lamm P</searchLink>; Artemed Hospital Munich South, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Tomasi+R%22">Tomasi R</searchLink>; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Unger+K%22">Unger K</searchLink>; Department of Radiotherapy and Radiooncology, LMU University Hospital, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Sperandio+M%22">Sperandio M</searchLink>; Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Center for Experimental Medicine, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kilger+E%22">Kilger E</searchLink>; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kreth+S%22">Kreth S</searchLink>; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany. simone.kreth@med.uni-muenchen.de.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany. simone.kreth@med.uni-muenchen.de.<br /><searchLink fieldCode="AU" term="%22Hübner+M%22">Hübner M</searchLink>; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany.
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