View in EDS

Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma.

Saved in:
Bibliographic Details
Title: Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma.
Authors: Bachem A; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia. Electronic address: abachem@unimelb.edu.au., Clarke M; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia., Kong G; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia; Centre for Pathogen Genomics Innovation Hub, Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia., Tarasova I; Computational Science Initiative, Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia., Dryburgh L; Computational Science Initiative, Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia., Kosack L; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia., Lee AR; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia., Newland LD; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia; Institute of Experimental Oncology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, North Rhine-Westphalia 53127, Germany., Wagner T; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia., Bawden E; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia., Yap KM; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3000, Australia., Wilson MD; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia., Engel S; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia., Wilson KR; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia., Russ BE; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3168, Australia., Tandon K; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia., Lau PKH; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3000, Australia; Melanoma Discovery Laboratory, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia; School of Medicine, University of Western Australia, Crawley, WA 6009, Australia., McArthur G; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3000, Australia; Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Marcelino VR; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia; Melbourne Integrative Genomics, School of BioSciences, The University of Melbourne, Melbourne, VIC 3010, Australia., Beavis PA; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3000, Australia., Turner SJ; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3168, Australia., Waithman J; School of Biomedical Sciences, The University of Western Australia, Perth, WA 6009, Australia; Telethon Kids Institute, The University of Western Australia, Perth, WA 6009, Australia., Stinear TP; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia; Centre for Pathogen Genomics Innovation Hub, Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia., Sandhu S; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3000, Australia; Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Schröder J; Computational Science Initiative, Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia., Gebhardt T; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia., Bedoui S; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia; Institute of Innate Immunity, University of Bonn, Bonn, North Rhine-Westphalia 53127, Germany. Electronic address: sbedoui@unimelb.edu.au.
Source: Immunity [Immunity] 2025 Nov 11; Vol. 58 (11), pp. 2799-2813.e8. Date of Electronic Publication: 2025 Nov 03.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41187761
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8<superscript>+</superscript> T cell immunity against melanoma.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Bachem+A%22">Bachem A</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia. Electronic address: abachem@unimelb.edu.au.<br /><searchLink fieldCode="AU" term="%22Clarke+M%22">Clarke M</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Kong+G%22">Kong G</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia; Centre for Pathogen Genomics Innovation Hub, Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Tarasova+I%22">Tarasova I</searchLink>; Computational Science Initiative, Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Dryburgh+L%22">Dryburgh L</searchLink>; Computational Science Initiative, Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Kosack+L%22">Kosack L</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Lee+AR%22">Lee AR</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Newland+LD%22">Newland LD</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia; Institute of Experimental Oncology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, North Rhine-Westphalia 53127, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+T%22">Wagner T</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Bawden+E%22">Bawden E</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Yap+KM%22">Yap KM</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Wilson+MD%22">Wilson MD</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Engel+S%22">Engel S</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Wilson+KR%22">Wilson KR</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Russ+BE%22">Russ BE</searchLink>; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3168, Australia.<br /><searchLink fieldCode="AU" term="%22Tandon+K%22">Tandon K</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Lau+PKH%22">Lau PKH</searchLink>; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3000, Australia; Melanoma Discovery Laboratory, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia; School of Medicine, University of Western Australia, Crawley, WA 6009, Australia.<br /><searchLink fieldCode="AU" term="%22McArthur+G%22">McArthur G</searchLink>; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3000, Australia; Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Marcelino+VR%22">Marcelino VR</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia; Melbourne Integrative Genomics, School of BioSciences, The University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Beavis+PA%22">Beavis PA</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Turner+SJ%22">Turner SJ</searchLink>; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3168, Australia.<br /><searchLink fieldCode="AU" term="%22Waithman+J%22">Waithman J</searchLink>; School of Biomedical Sciences, The University of Western Australia, Perth, WA 6009, Australia; Telethon Kids Institute, The University of Western Australia, Perth, WA 6009, Australia.<br /><searchLink fieldCode="AU" term="%22Stinear+TP%22">Stinear TP</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia; Centre for Pathogen Genomics Innovation Hub, Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Sandhu+S%22">Sandhu S</searchLink>; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3000, Australia; Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Schröder+J%22">Schröder J</searchLink>; Computational Science Initiative, Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Gebhardt+T%22">Gebhardt T</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Bedoui+S%22">Bedoui S</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia; Institute of Innate Immunity, University of Bonn, Bonn, North Rhine-Westphalia 53127, Germany. Electronic address: sbedoui@unimelb.edu.au.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229432918%22">Immunity</searchLink> [Immunity] 2025 Nov 11; Vol. 58 (11), pp. 2799-2813.e8. <i>Date of Electronic Publication: </i>2025 Nov 03.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9432918 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-4180 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210747613%22">10747613 </searchLink><i>NLM ISO Abbreviation: </i>Immunity <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41187761
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.immuni.2025.10.004
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2799
    Titles:
      – TitleFull: Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Bachem A
      – PersonEntity:
          Name:
            NameFull: Clarke M
      – PersonEntity:
          Name:
            NameFull: Kong G
      – PersonEntity:
          Name:
            NameFull: Tarasova I
      – PersonEntity:
          Name:
            NameFull: Dryburgh L
      – PersonEntity:
          Name:
            NameFull: Kosack L
      – PersonEntity:
          Name:
            NameFull: Lee AR
      – PersonEntity:
          Name:
            NameFull: Newland LD
      – PersonEntity:
          Name:
            NameFull: Wagner T
      – PersonEntity:
          Name:
            NameFull: Bawden E
      – PersonEntity:
          Name:
            NameFull: Yap KM
      – PersonEntity:
          Name:
            NameFull: Wilson MD
      – PersonEntity:
          Name:
            NameFull: Engel S
      – PersonEntity:
          Name:
            NameFull: Wilson KR
      – PersonEntity:
          Name:
            NameFull: Russ BE
      – PersonEntity:
          Name:
            NameFull: Tandon K
      – PersonEntity:
          Name:
            NameFull: Lau PKH
      – PersonEntity:
          Name:
            NameFull: McArthur G
      – PersonEntity:
          Name:
            NameFull: Marcelino VR
      – PersonEntity:
          Name:
            NameFull: Beavis PA
      – PersonEntity:
          Name:
            NameFull: Turner SJ
      – PersonEntity:
          Name:
            NameFull: Waithman J
      – PersonEntity:
          Name:
            NameFull: Stinear TP
      – PersonEntity:
          Name:
            NameFull: Sandhu S
      – PersonEntity:
          Name:
            NameFull: Schröder J
      – PersonEntity:
          Name:
            NameFull: Gebhardt T
      – PersonEntity:
          Name:
            NameFull: Bedoui S
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 11
              M: 11
              Text: 2025 Nov 11
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1097-4180
          Numbering:
            – Type: volume
              Value: 58
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: Immunity
              Type: main
ResultId 1