Genome edited intestine liver on a chip system for integrated intestinal hepatic drug absorption and metabolism evaluation.
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| Title: | Genome edited intestine liver on a chip system for integrated intestinal hepatic drug absorption and metabolism evaluation. |
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| Authors: | Negoro R; Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, 525-8577, Japan. negoro-r@fc.ritsumei.ac.jp., Deguchi S; Department of Synthetic Human Body System, Medical Research Institute, Institute of Integrated Research, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Yamazaki D; Division of Pharmacology, Center for Biological Safety and Research, National Institute of Health Sciences, 3-25-26 Tono-machi, Kawasaki-ku, Kawasaki, 210-9501, Japan., Takayama K; Department of Synthetic Human Body System, Medical Research Institute, Institute of Integrated Research, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Fujita T; Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, 525-8577, Japan. |
| Source: | Scientific reports [Sci Rep] 2025 Nov 04; Vol. 15 (1), pp. 38609. Date of Electronic Publication: 2025 Nov 04. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2045-2322 |
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| DOI: | 10.1038/s41598-025-22425-0 |
