PKCβ Inhibitor MS-553 Displays Preclinical Efficacy in Both Treatment-Naïve and BTK Inhibitor-Resistant Chronic Lymphocytic Leukemia.

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Title: PKCβ Inhibitor MS-553 Displays Preclinical Efficacy in Both Treatment-Naïve and BTK Inhibitor-Resistant Chronic Lymphocytic Leukemia.
Authors: Gordon BK; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Muhowski EM; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio., Singh J; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Ravikrishnan J; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Peris-Cuesta A; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Diaz Rohena D; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Sanchez JR; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Thangavadivel S; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Benrashid S; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., He A; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Marr AR; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Mitchell AD; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio., Urrutia JM; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Misra S; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Lai TH; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Yu L; Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio., Walker BR; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Perry E; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Shukla SA; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Grieselhuber NR; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Rogers KA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Lapalombella R; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Blachly JS; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Kittai AS; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Bhat SA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Jain N; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Wierda WG; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Byrd JC; Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio., Niesman M; MingSight Pharmaceuticals Inc., San Diego, California., Zhang K; MingSight Pharmaceuticals Inc., San Diego, California., Sampath D; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Woyach JA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
Source: Blood cancer discovery [Blood Cancer Discov] 2026 Jan 12; Vol. 7 (1), pp. 85-103.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101764786 Publication Model: Print Cited Medium: Internet ISSN: 2643-3249 (Electronic) Linking ISSN: 26433230 NLM ISO Abbreviation: Blood Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2643-3249
DOI:10.1158/2643-3230.BCD-25-0114