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Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology.

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Title: Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology.
Authors: Burger D; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland., Kashyrina M; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France.; Laboratory of Human Anatomy, Department of Experimental Medicine, Univ. Salento, Lecce, Italy., van den Heuvel L; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland., de La Seiglière H; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France., Lewis AJ; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland., De Nuccio F; Laboratory of Human Anatomy, Department of Experimental Medicine, Univ. Salento, Lecce, Italy., Mohammed I; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland.; Dubochet Center for Imaging, Lausanne, Genopode (UNIL), EPFL, Lausanne, Switzerland., Verchère J; Neurodegenerative Diseases Unit, ANSES, Univ. Lyon, Lyon, France., Feuillie C; Institut de Chimie et Biologie des Membranes et des Nano-objets, UMR 5248, Univ. Bordeaux, CNRS, Bordeaux INP, Pessac, France., Berbon M; Institut de Chimie et Biologie des Membranes et des Nano-objets, UMR 5248, Univ. Bordeaux, CNRS, Bordeaux INP, Pessac, France., Arotcarena ML; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France., Retailleau A; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France., Bezard E; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France., Canron MH; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France., Meissner WG; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France.; Service de Neurologie des Maladies Neurodégénératives, IMNc, CHU Bordeaux, Bordeaux, France., Loquet A; Institut de Chimie et Biologie des Membranes et des Nano-objets, UMR 5248, Univ. Bordeaux, CNRS, Bordeaux INP, Pessac, France., Bousset L; Laboratoire des Maladies Neurodégénératives, UMR 9199, Univ. Paris-Saclay, CNRS, CEA, Fontenay-aux-Roses, France., Poujol C; Bordeaux Imaging Center, UAR 3420, US 4, Univ. Bordeaux, CNRS, INSERM, Bordeaux, France., Nilsson KPR; Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden., Laferrière F; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France., Baron T; Neurodegenerative Diseases Unit, ANSES, Univ. Lyon, Lyon, France., Lofrumento DD; Laboratory of Human Anatomy, Department of Biological and Environmental Sciences and Technologies, Univ. Salento, Lecce, Italy., De Giorgi F; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France., Stahlberg H; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland. henning.stahlberg@epfl.ch.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland. henning.stahlberg@epfl.ch., Ichas F; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France. francois.ichas@inserm.fr.; Laboratory of Human Anatomy, Department of Biological and Environmental Sciences and Technologies, Univ. Salento, Lecce, Italy. francois.ichas@inserm.fr.
Source: Nature [Nature] 2025 Dec; Vol. 648 (8093), pp. 409-417. Date of Electronic Publication: 2025 Nov 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology.
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  Data: <searchLink fieldCode="AU" term="%22Burger+D%22">Burger D</searchLink>; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kashyrina+M%22">Kashyrina M</searchLink>; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France.; Laboratory of Human Anatomy, Department of Experimental Medicine, Univ. Salento, Lecce, Italy.<br /><searchLink fieldCode="AU" term="%22van+den+Heuvel+L%22">van den Heuvel L</searchLink>; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22de+La+Seiglière+H%22">de La Seiglière H</searchLink>; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Lewis+AJ%22">Lewis AJ</searchLink>; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22De+Nuccio+F%22">De Nuccio F</searchLink>; Laboratory of Human Anatomy, Department of Experimental Medicine, Univ. Salento, Lecce, Italy.<br /><searchLink fieldCode="AU" term="%22Mohammed+I%22">Mohammed I</searchLink>; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland.; Dubochet Center for Imaging, Lausanne, Genopode (UNIL), EPFL, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Verchère+J%22">Verchère J</searchLink>; Neurodegenerative Diseases Unit, ANSES, Univ. Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Feuillie+C%22">Feuillie C</searchLink>; Institut de Chimie et Biologie des Membranes et des Nano-objets, UMR 5248, Univ. Bordeaux, CNRS, Bordeaux INP, Pessac, France.<br /><searchLink fieldCode="AU" term="%22Berbon+M%22">Berbon M</searchLink>; Institut de Chimie et Biologie des Membranes et des Nano-objets, UMR 5248, Univ. Bordeaux, CNRS, Bordeaux INP, Pessac, France.<br /><searchLink fieldCode="AU" term="%22Arotcarena+ML%22">Arotcarena ML</searchLink>; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Retailleau+A%22">Retailleau A</searchLink>; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Bezard+E%22">Bezard E</searchLink>; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Canron+MH%22">Canron MH</searchLink>; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Meissner+WG%22">Meissner WG</searchLink>; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France.; Service de Neurologie des Maladies Neurodégénératives, IMNc, CHU Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Loquet+A%22">Loquet A</searchLink>; Institut de Chimie et Biologie des Membranes et des Nano-objets, UMR 5248, Univ. Bordeaux, CNRS, Bordeaux INP, Pessac, France.<br /><searchLink fieldCode="AU" term="%22Bousset+L%22">Bousset L</searchLink>; Laboratoire des Maladies Neurodégénératives, UMR 9199, Univ. Paris-Saclay, CNRS, CEA, Fontenay-aux-Roses, France.<br /><searchLink fieldCode="AU" term="%22Poujol+C%22">Poujol C</searchLink>; Bordeaux Imaging Center, UAR 3420, US 4, Univ. Bordeaux, CNRS, INSERM, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Nilsson+KPR%22">Nilsson KPR</searchLink>; Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.<br /><searchLink fieldCode="AU" term="%22Laferrière+F%22">Laferrière F</searchLink>; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Baron+T%22">Baron T</searchLink>; Neurodegenerative Diseases Unit, ANSES, Univ. Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Lofrumento+DD%22">Lofrumento DD</searchLink>; Laboratory of Human Anatomy, Department of Biological and Environmental Sciences and Technologies, Univ. Salento, Lecce, Italy.<br /><searchLink fieldCode="AU" term="%22De+Giorgi+F%22">De Giorgi F</searchLink>; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Stahlberg+H%22">Stahlberg H</searchLink>; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland. henning.stahlberg@epfl.ch.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland. henning.stahlberg@epfl.ch.<br /><searchLink fieldCode="AU" term="%22Ichas+F%22">Ichas F</searchLink>; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France. francois.ichas@inserm.fr.; Laboratory of Human Anatomy, Department of Biological and Environmental Sciences and Technologies, Univ. Salento, Lecce, Italy. francois.ichas@inserm.fr.
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