Anti-progestin therapy targets hallmarks of breast cancer risk.

Saved in:
Bibliographic Details
Title: Anti-progestin therapy targets hallmarks of breast cancer risk.
Authors: Simões BM; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. bruno.simoes@manchester.ac.uk., Pedley R; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Manchester Cell-Matrix Centre, University of Manchester, Manchester, UK.; Medicines Discovery Catapult, Alderley Park, Cheshire, UK., McCloskey CW; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.; UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Roberts M; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Reed AD; Department of Pharmacology, University of Cambridge and Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Twigger AJ; Department of Pharmacology, University of Cambridge and Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Tharmapalan P; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Caruso A; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Department of Pharmacy, Health and Nutritional Sciences, Health Center, University of Calabria, Cosenza, Italy., Cabral S; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Wilby AJ; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Harrison H; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Zhou Y; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Manchester Cell-Matrix Centre, University of Manchester, Manchester, UK., Greenhalgh A; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Alghamdi SA; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Forestiero M; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Department of Pharmacy, Health and Nutritional Sciences, Health Center, University of Calabria, Cosenza, Italy., Lopez-Muñoz J; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Roche J; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Tuieng RJ; Division of Cell Matrix Biology & Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Khan MA; Manchester Cell-Matrix Centre, University of Manchester, Manchester, UK., Squires S; Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Astley SM; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Harkness EF; Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Santiago-Gómez A; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Spence K; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Ritchie J; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK., Pritchard S; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK., Lim Y; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK., Sherratt MJ; Division of Cell Matrix Biology & Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Andò S; Department of Pharmacy, Health and Nutritional Sciences, Health Center, University of Calabria, Cosenza, Italy., Howell A; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK., Evans DG; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.; Manchester Centre for Genomic Medicine, Division of Evolution, Infection and Genomic Health, University of Manchester and St Mary's Hospital, Manchester, UK., Gilmore AP; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Manchester Cell-Matrix Centre, University of Manchester, Manchester, UK., Khaled WT; Department of Pharmacology, University of Cambridge and Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Khokha R; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Clarke RB; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. robert.clarke@manchester.ac.uk., Howell SJ; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. sacha.howell@nhs.net.; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK. sacha.howell@nhs.net.; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK. sacha.howell@nhs.net.
Source: Nature [Nature] 2025 Dec; Vol. 648 (8094), pp. 736-745. Date of Electronic Publication: 2025 Nov 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-025-09684-7