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A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis.

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Title: A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis.
Authors: Nguyen TA; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Lin JG; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Marques AMC; Centre for Medicines Discovery, Nuffield Department of Medicine, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, Oxford, UK., Fottner M; Laboratory for Organic Chemistry (LOC), Department of Chemistry and Applied Biosciences (D-CHAB), ETH Zurich, Zurich, Switzerland., Bauer LG; Centre for Medicines Discovery, Nuffield Department of Medicine, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, Oxford, UK., Reicher A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Daum D; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Scrofani L; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Liu Y; Centre for Medicines Discovery, Nuffield Department of Medicine, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, Oxford, UK., Cheng C; Centre for Medicines Discovery, Nuffield Department of Medicine, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, Oxford, UK., D'Angelo L D D L; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Sanchez J; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Bueschl C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Marella N; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Buphamalai P; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Vienna, Austria., Traversi F; Division of Metabolism and Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland., Bereš M; Institute of Pharmacology, Center of Physiology and Pharmacology & Comprehensive Cancer Center (CCC), Medical University of Vienna, Vienna, Austria., Moll HP; Institute of Pharmacology, Center of Physiology and Pharmacology & Comprehensive Cancer Center (CCC), Medical University of Vienna, Vienna, Austria., Siklos M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Genger JW; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Hofstaetter G; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Villanti L; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Malik M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Klimek C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Runggatscher K; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Guertl B; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Hansen JS; Centre for Medicines Discovery, Nuffield Department of Medicine, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, Oxford, UK., Dobner S; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Babosova O; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Becirovic T; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., de Rooij LPMH; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Casanova E; Institute of Pharmacology, Center of Physiology and Pharmacology & Comprehensive Cancer Center (CCC), Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Koren A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Froese DS; Division of Metabolism and Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland., Rosenblatt DS; Department of Human Genetics, McGill University, Montreal, Canada., Klavins K; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Bergthaler A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Institute for Hygiene and Applied Immunology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Menche J; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Vienna, Austria., Hannich JT; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Abele M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Sdelci S; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Center for Genomic Regulation, Barcelona, Spain., Lang K; Laboratory for Organic Chemistry (LOC), Department of Chemistry and Applied Biosciences (D-CHAB), ETH Zurich, Zurich, Switzerland., Huber KVM; Centre for Medicines Discovery, Nuffield Department of Medicine, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, Oxford, UK., Kubicek S; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Source: Science (New York, N.Y.) [Science] 2025 Dec 11; Vol. 390 (6778), pp. 1143-1150. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1095-9203
DOI:10.1126/science.adv4257