PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors.
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| Title: | PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors. |
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| Authors: | Huber AD; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Lin W; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Jung YH; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Poudel S; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Yang G; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Wu J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Carrigan AG; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Pagala V; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Wang W; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Fu Y; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Yuan ZF; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Byrum SD; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Yang K; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Gee RRF; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.; Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Arnold ED; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA., Loughran AJ; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA., Wang J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Pruett-Miller SM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA., Peng J; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Chen T; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA. taosheng.chen@stjude.org. |
| Source: | Nature communications [Nat Commun] 2025 Nov 06; Vol. 16 (1), pp. 9805. Date of Electronic Publication: 2025 Nov 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-64773-5 |
