Mutation of CMTR2 in Lung Adenocarcinoma Alters RNA Alternative Splicing and Reveals Therapeutic Vulnerabilities.
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| Title: | Mutation of CMTR2 in Lung Adenocarcinoma Alters RNA Alternative Splicing and Reveals Therapeutic Vulnerabilities. |
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| Authors: | Nukaga S; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan., Shiraishi K; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.; Department of Clinical Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Hamabe K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan., Mochizuki A; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Hamaguchi Y; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Ogawa E; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Le NT; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Shimada Y; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Ono H; Department of Clinical Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Nishinakamura H; Division of Cancer Immunology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Kobayashi Y; Division of Molecular Pathology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Hamamoto J; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan., Ui A; Department of Molecular Oncology, IDAC Fellow Laboratory, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan., Araki M; Graduate School of Medicine, Kyoto University, Kyoto, Japan., Sagae Y; Graduate School of Medicine, Kyoto University, Kyoto, Japan., Ohgino K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan., Sugihara K; Division of Pulmonary Medicine, Kawasaki Municipal Hospital, Kawasaki-ku, Kanagawa, Japan., Endo S; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Miyakoshi J; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Shiraishi Y; Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Yasuda H; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan., Okuno Y; Graduate School of Medicine, Kyoto University, Kyoto, Japan., Yoshida T; Department of Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Goto Y; Department of Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Ohe Y; Department of Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Watanabe SI; Department of Thoracic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Yatabe Y; Division of Molecular Pathology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.; Department of Diagnostic Pathology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Nishikawa H; Division of Cancer Immunology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Hamamoto R; Division of Medical AI Research and Development, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Kohno T; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. tkkohno@ncc.go.jp., Nakaoku T; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. tnakaoku@ncc.go.jp. |
| Source: | Nature communications [Nat Commun] 2025 Nov 06; Vol. 16 (1), pp. 9754. Date of Electronic Publication: 2025 Nov 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-64821-0 |
