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Mutation of CMTR2 in Lung Adenocarcinoma Alters RNA Alternative Splicing and Reveals Therapeutic Vulnerabilities.

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Title: Mutation of CMTR2 in Lung Adenocarcinoma Alters RNA Alternative Splicing and Reveals Therapeutic Vulnerabilities.
Authors: Nukaga S; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan., Shiraishi K; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.; Department of Clinical Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Hamabe K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan., Mochizuki A; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Hamaguchi Y; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Ogawa E; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Le NT; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Shimada Y; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Ono H; Department of Clinical Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Nishinakamura H; Division of Cancer Immunology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Kobayashi Y; Division of Molecular Pathology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Hamamoto J; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan., Ui A; Department of Molecular Oncology, IDAC Fellow Laboratory, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan., Araki M; Graduate School of Medicine, Kyoto University, Kyoto, Japan., Sagae Y; Graduate School of Medicine, Kyoto University, Kyoto, Japan., Ohgino K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan., Sugihara K; Division of Pulmonary Medicine, Kawasaki Municipal Hospital, Kawasaki-ku, Kanagawa, Japan., Endo S; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Miyakoshi J; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Shiraishi Y; Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Yasuda H; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan., Okuno Y; Graduate School of Medicine, Kyoto University, Kyoto, Japan., Yoshida T; Department of Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Goto Y; Department of Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Ohe Y; Department of Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Watanabe SI; Department of Thoracic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Yatabe Y; Division of Molecular Pathology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.; Department of Diagnostic Pathology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Nishikawa H; Division of Cancer Immunology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Hamamoto R; Division of Medical AI Research and Development, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Kohno T; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. tkkohno@ncc.go.jp., Nakaoku T; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. tnakaoku@ncc.go.jp.
Source: Nature communications [Nat Commun] 2025 Nov 06; Vol. 16 (1), pp. 9754. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Mutation of CMTR2 in Lung Adenocarcinoma Alters RNA Alternative Splicing and Reveals Therapeutic Vulnerabilities.
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  Data: <searchLink fieldCode="AU" term="%22Nukaga+S%22">Nukaga S</searchLink>; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Shiraishi+K%22">Shiraishi K</searchLink>; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.; Department of Clinical Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hamabe+K%22">Hamabe K</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Mochizuki+A%22">Mochizuki A</searchLink>; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hamaguchi+Y%22">Hamaguchi Y</searchLink>; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ogawa+E%22">Ogawa E</searchLink>; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Le+NT%22">Le NT</searchLink>; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Shimada+Y%22">Shimada Y</searchLink>; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ono+H%22">Ono H</searchLink>; Department of Clinical Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nishinakamura+H%22">Nishinakamura H</searchLink>; Division of Cancer Immunology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+Y%22">Kobayashi Y</searchLink>; Division of Molecular Pathology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hamamoto+J%22">Hamamoto J</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ui+A%22">Ui A</searchLink>; Department of Molecular Oncology, IDAC Fellow Laboratory, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Araki+M%22">Araki M</searchLink>; Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Sagae+Y%22">Sagae Y</searchLink>; Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Ohgino+K%22">Ohgino K</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sugihara+K%22">Sugihara K</searchLink>; Division of Pulmonary Medicine, Kawasaki Municipal Hospital, Kawasaki-ku, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Endo+S%22">Endo S</searchLink>; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Miyakoshi+J%22">Miyakoshi J</searchLink>; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Shiraishi+Y%22">Shiraishi Y</searchLink>; Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yasuda+H%22">Yasuda H</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Okuno+Y%22">Okuno Y</searchLink>; Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshida+T%22">Yoshida T</searchLink>; Department of Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Goto+Y%22">Goto Y</searchLink>; Department of Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ohe+Y%22">Ohe Y</searchLink>; Department of Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+SI%22">Watanabe SI</searchLink>; Department of Thoracic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yatabe+Y%22">Yatabe Y</searchLink>; Division of Molecular Pathology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.; Department of Diagnostic Pathology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nishikawa+H%22">Nishikawa H</searchLink>; Division of Cancer Immunology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hamamoto+R%22">Hamamoto R</searchLink>; Division of Medical AI Research and Development, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kohno+T%22">Kohno T</searchLink>; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. tkkohno@ncc.go.jp.<br /><searchLink fieldCode="AU" term="%22Nakaoku+T%22">Nakaoku T</searchLink>; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. tnakaoku@ncc.go.jp.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Nov 06; Vol. 16 (1), pp. 9754. <i>Date of Electronic Publication: </i>2025 Nov 06.
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