Berberine and berberrubine promote the expression of CYP3A4 via enhancing the binding of nuclear receptor PXR.

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Title: Berberine and berberrubine promote the expression of CYP3A4 via enhancing the binding of nuclear receptor PXR.
Authors: Xiao GM; Ganzhou People's Hospital, Ganzhou, 341000, China., Lu T; The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China., Zhu D; Institute of Clinical Pharmacology, Nanchang University, Nanchang, 330006, China., Liu MY; Ganzhou People's Hospital, Ganzhou, 341000, China. liumingyi823@126.com.; The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China. liumingyi823@126.com.
Source: BMC pharmacology & toxicology [BMC Pharmacol Toxicol] 2025 Nov 06; Vol. 26 (1), pp. 187. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101590449 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-6511 (Electronic) Linking ISSN: 20506511 NLM ISO Abbreviation: BMC Pharmacol Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2050-6511
DOI:10.1186/s40360-025-01026-7