Age-diet interactions significantly influence intratumoral gene expression, gut microbiome signature and tumor microenvironment in colorectal cancer.

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Title: Age-diet interactions significantly influence intratumoral gene expression, gut microbiome signature and tumor microenvironment in colorectal cancer.
Authors: Soni S; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Mittal P; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Lo JH; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Yang Y; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, USA., Smbatyan G; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Lee K; Translational Genomics Research Institute (TGen North), part of City of Hope, Flagstaff, AZ, USA., Wan J; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Kumagai H; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Yen K; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Mehta HH; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Miller B; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Torres-Gonzalez L; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Battaglin F; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Shah UH; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Bartolini M; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Zhang W; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Craig DW; Department of Integrative Translational Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA., Millstein J; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, USA., Cohen P; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Lenz HJ; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: lenz@usc.edu.
Source: Neoplasia (New York, N.Y.) [Neoplasia] 2025 Dec; Vol. 70, pp. 101245. Date of Electronic Publication: 2025 Oct 25.
Publication Type: Journal Article; Research Support, N.I.H., Intramural
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5586
DOI:10.1016/j.neo.2025.101245