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Age-diet interactions significantly influence intratumoral gene expression, gut microbiome signature and tumor microenvironment in colorectal cancer.

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Title: Age-diet interactions significantly influence intratumoral gene expression, gut microbiome signature and tumor microenvironment in colorectal cancer.
Authors: Soni S; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Mittal P; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Lo JH; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Yang Y; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, USA., Smbatyan G; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Lee K; Translational Genomics Research Institute (TGen North), part of City of Hope, Flagstaff, AZ, USA., Wan J; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Kumagai H; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Yen K; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Mehta HH; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Miller B; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Torres-Gonzalez L; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Battaglin F; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Shah UH; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Bartolini M; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Zhang W; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Craig DW; Department of Integrative Translational Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA., Millstein J; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, USA., Cohen P; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Lenz HJ; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: lenz@usc.edu.
Source: Neoplasia (New York, N.Y.) [Neoplasia] 2025 Dec; Vol. 70, pp. 101245. Date of Electronic Publication: 2025 Oct 25.
Publication Type: Journal Article; Research Support, N.I.H., Intramural
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Age-diet interactions significantly influence intratumoral gene expression, gut microbiome signature and tumor microenvironment in colorectal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Soni+S%22">Soni S</searchLink>; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mittal+P%22">Mittal P</searchLink>; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lo+JH%22">Lo JH</searchLink>; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, USA.<br /><searchLink fieldCode="AU" term="%22Smbatyan+G%22">Smbatyan G</searchLink>; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+K%22">Lee K</searchLink>; Translational Genomics Research Institute (TGen North), part of City of Hope, Flagstaff, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Wan+J%22">Wan J</searchLink>; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kumagai+H%22">Kumagai H</searchLink>; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yen+K%22">Yen K</searchLink>; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mehta+HH%22">Mehta HH</searchLink>; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Miller+B%22">Miller B</searchLink>; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Torres-Gonzalez+L%22">Torres-Gonzalez L</searchLink>; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Battaglin+F%22">Battaglin F</searchLink>; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shah+UH%22">Shah UH</searchLink>; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bartolini+M%22">Bartolini M</searchLink>; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Craig+DW%22">Craig DW</searchLink>; Department of Integrative Translational Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Millstein+J%22">Millstein J</searchLink>; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+P%22">Cohen P</searchLink>; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lenz+HJ%22">Lenz HJ</searchLink>; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: lenz@usc.edu.
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  Data: <searchLink fieldCode="JN" term="%22100886622%22">Neoplasia (New York, N.Y.)</searchLink> [Neoplasia] 2025 Dec; Vol. 70, pp. 101245. <i>Date of Electronic Publication: </i>2025 Oct 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100886622 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5586 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214765586%22">14765586 </searchLink><i>NLM ISO Abbreviation: </i>Neoplasia <i>Subsets: </i>MEDLINE
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      – TitleFull: Age-diet interactions significantly influence intratumoral gene expression, gut microbiome signature and tumor microenvironment in colorectal cancer.
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              Text: 2025 Dec
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