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Targeted delivery of the GPX4 activator via HUCMSC-derived exosomes inhibits ferroptosis in spinal cord injury.

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Title: Targeted delivery of the GPX4 activator via HUCMSC-derived exosomes inhibits ferroptosis in spinal cord injury.
Authors: Fan B; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China., Gao X; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China., Chen X; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China., Liu X; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China., Wen P; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China., Ren Y; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China., Huang B; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China., Li J; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China., Ran N; Institute of Medical Sciences, Cheeloo College of Medicine, The Second Hospital of Shandong University, Shandong University, 247 Beiyuan Street, Jinan, 250033, Shandong, China., Ding H; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China., Ren Y; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China., Shi Z; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China., Sun C; Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, 300052, Tianjin, China., Wang F; Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, 300052, Tianjin, China., Hao Y; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China., Liu T; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China. liu_tao_tj@163.com., Ning G; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China. gzning@tmu.edu.cn., Yao X; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China. xueyao@tmu.edu.cn., Feng S; Department of Orthopaedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Institute of Orthopaedic Innovation and Translation, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin, 300052, China. sqfeng@tmu.edu.cn.; Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China. sqfeng@tmu.edu.cn.; Institute of Medical Sciences, Cheeloo College of Medicine, The Second Hospital of Shandong University, Shandong University, 247 Beiyuan Street, Jinan, 250033, Shandong, China. sqfeng@tmu.edu.cn.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2025 Nov 08; Vol. 23 (1), pp. 707. Date of Electronic Publication: 2025 Nov 08.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1477-3155
DOI:10.1186/s12951-025-03755-7