Efficacy, all-cause discontinuation, and safety of serotonergic psychedelics and MDMA to treat mental disorders: A living systematic review with meta-analysis.

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Title: Efficacy, all-cause discontinuation, and safety of serotonergic psychedelics and MDMA to treat mental disorders: A living systematic review with meta-analysis.
Authors: Højlund M; Department of Psychiatry Aabenraa, Mental Health Services in the Region of Southern Denmark, Aabenraa, Denmark; Clinical Pharmacology, Pharmacy, and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark., Kafali HY; Department of Psychology, Fevziye Schools Fundations Işık University, Istanbul, Turkey., Kırmızı B; Department of Child and Adolescent Psychiatry, Ankara City Hospital, Ankara, Turkey., Fusar-Poli P; Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, King's College London, UK; Department of Brain and Behavioral Sciences, University of Pavia, Italy; Outreach and Support in South-London (OASIS) service, South London and Maudlsey (SLaM) NHS Foundation Trust, UK; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University (LMU), Munich, Germany., Correll CU; Center for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, NY, USA; Department of Psychiatry, Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany., Cortese S; Developmental EPI (Evidence synthesis, Prediction, Implementation) Lab, Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK; Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK; Hampshire and Isle of Wight Healthcare NHS Foundation Trust, Southampton, UK; Hassenfeld Children's Hospital at NYU Langone, New York University Child Study Center, New York City, NY, USA; DiMePRe-J - Department of Precision and Regenerative Medicine and Ionian Area, University of Bari 'Aldo Moro', Bari, Italy., Sabé M; Division of Adult Psychiatry, Department of Psychiatry, University Hospitals of Geneva, Thonex, Switzerland; Faculty of Medicine, University of Geneva, Geneva, Switzerland; Division of Addiction Psychiatry, Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland., Fiedorowicz J; Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute (OHRI), University of Ottawa, Ottawa, Canada; Department of Mental Health, The Ottawa Hospital, Ottawa, Ontario, Canada., Saraf G; Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute (OHRI), University of Ottawa, Ottawa, Canada; Department of Mental Health, The Ottawa Hospital, Ottawa, Ontario, Canada., Zein J; Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada., Berk M; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Victoria, Australia., Husain MI; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Temerty Centre for Therapeutic Brain Intervention, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Rosenblat JD; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Mood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for Depression, University Health Network, Toronto, ON, Canada., Rubaiyat R; Ottawa Hospital Research Institute (OHRI), University of Ottawa, Ottawa, Canada., Corace K; Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada; Department of Mental Health, The Ottawa Hospital, Ottawa, Ontario, Canada; Canadian Centre on Substance Use and Addiction, Ottawa, Ontario, Canada., Wong S; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada., Hatcher S; Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute (OHRI), University of Ottawa, Ottawa, Canada., Kaluzienski M; Department of Mental Health, The Ottawa Hospital, Ottawa, Ontario, Canada., Yatham LN; Department of Psychiatry, University of British Columbia, Vancouver, Canada; Institute of Mental Health, University of British Columbia, Vancouver, Canada., Cipriani A; Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Precision Psychiatry Lab, NIHR Oxford Health Biomedical Research Centre, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK; NIHR Oxford Health Clinical Research Facility, Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK., Gosling CJ; Developmental EPI (Evidence synthesis, Prediction, Implementation) Lab, Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK; DysCo Lab, Department of Psychology, Université Paris Nanterre, Paris, France; Service de psychiatrie de l'enfant et de l'adolescent, Hôpital Robert Debré, Paris, France., Carhart-Harris R; Department of Medicine, Centre for Psychedelic Research, Imperial College London, London, UK; Psychedelics Division, Neuroscape, Department of Neurology, University of California San Francisco, San Francisco, United States., Tanuseputro P; Department of Family Medicine and Primary Care, The University of Hong Kong, Hong Kong., Myran DT; Ottawa Hospital Research Institute (OHRI), University of Ottawa, Ottawa, Canada; Institute for Clinical Evaluative Sciences, University of Ottawa, Ottawa, Ontario, Canada; Department of Family Medicine, University of Ottawa, Ottawa, Ontario, Canada; Bruyère Research Institute, Ottawa, Ontario, Canada., Fabiano N; Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada., Moher D; Centre of Journalology, Methodological and Implementation Research Program, Ottawa Hospital Research Institute, Ottawa, Canada., Mayo LM; Department of Psychiatry, Cumming School of Medicine, Mathison Centre for Mental Health Research and Education, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada., Nicholls SG; Methodological and Implementation Research (MIR) Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., White T; Ottawa Hospital Research Institute (OHRI), University of Ottawa, Ottawa, Canada., Prisco M; Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain., Radua J; Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain., Vieta E; Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain., Ladha KS; Department of Anesthesiology, St. Michael's Hospital, Toronto, Canada; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Canada., Katz J; Psychedelic Association of Canada, Canada., Veroniki AA; Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada; Center for Evidence Synthesis in Health, Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, Rhode Island, USA., Solmi M; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany; Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute (OHRI), University of Ottawa, Ottawa, Canada; Department of Mental Health, The Ottawa Hospital, Ottawa, Ontario, Canada. Electronic address: msolmi@toh.ca.
Source: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2025 Dec; Vol. 101, pp. 41-55. Date of Electronic Publication: 2025 Nov 07.
Publication Type: Journal Article; Systematic Review; Meta-Analysis
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9111390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7862 (Electronic) Linking ISSN: 0924977X NLM ISO Abbreviation: Eur Neuropsychopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-7862
DOI:10.1016/j.euroneuro.2025.09.011