Safety, tolerability, and immunogenicity of INO-4500, a synthetic DNA-based vaccine against Lassa virus, in a phase 1b clinical trial in healthy Ghanaian adults.
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| Title: | Safety, tolerability, and immunogenicity of INO-4500, a synthetic DNA-based vaccine against Lassa virus, in a phase 1b clinical trial in healthy Ghanaian adults. |
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| Authors: | Koram KA; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Walker KA; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Orizu B; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Marrero I; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Boyer J; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Yang S; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Broderick KE; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Kusi KA; Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Kyei-Baafour E; Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Ofori EA; Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Pobee A; Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Adu-Amankwah S; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Amoakoh-Coleman M; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Amoakoh HB; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.; Department of Global Public Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University, Utrecht, Netherlands., Abuaku B; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Badji E; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Ntiri M; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Quaye L; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Morrow MP; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Sylvester AJ; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Reuschel EL; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Gillespie E; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Liebowitz D; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Humeau LM; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States. |
| Source: | Frontiers in immunology [Front Immunol] 2025 Oct 24; Vol. 16, pp. 1658549. Date of Electronic Publication: 2025 Oct 24 (Print Publication: 2025). |
| Publication Type: | Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2025.1658549 |
