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Safety, tolerability, and immunogenicity of INO-4500, a synthetic DNA-based vaccine against Lassa virus, in a phase 1b clinical trial in healthy Ghanaian adults.

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Title: Safety, tolerability, and immunogenicity of INO-4500, a synthetic DNA-based vaccine against Lassa virus, in a phase 1b clinical trial in healthy Ghanaian adults.
Authors: Koram KA; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Walker KA; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Orizu B; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Marrero I; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Boyer J; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Yang S; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Broderick KE; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Kusi KA; Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Kyei-Baafour E; Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Ofori EA; Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Pobee A; Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Adu-Amankwah S; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Amoakoh-Coleman M; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Amoakoh HB; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.; Department of Global Public Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University, Utrecht, Netherlands., Abuaku B; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Badji E; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Ntiri M; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Quaye L; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Morrow MP; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Sylvester AJ; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Reuschel EL; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Gillespie E; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Liebowitz D; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Humeau LM; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.
Source: Frontiers in immunology [Front Immunol] 2025 Oct 24; Vol. 16, pp. 1658549. Date of Electronic Publication: 2025 Oct 24 (Print Publication: 2025).
Publication Type: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: Safety, tolerability, and immunogenicity of INO-4500, a synthetic DNA-based vaccine against Lassa virus, in a phase 1b clinical trial in healthy Ghanaian adults.
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  Data: <searchLink fieldCode="AU" term="%22Koram+KA%22">Koram KA</searchLink>; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.<br /><searchLink fieldCode="AU" term="%22Walker+KA%22">Walker KA</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Orizu+B%22">Orizu B</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Marrero+I%22">Marrero I</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Boyer+J%22">Boyer J</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Broderick+KE%22">Broderick KE</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Kusi+KA%22">Kusi KA</searchLink>; Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.<br /><searchLink fieldCode="AU" term="%22Kyei-Baafour+E%22">Kyei-Baafour E</searchLink>; Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.<br /><searchLink fieldCode="AU" term="%22Ofori+EA%22">Ofori EA</searchLink>; Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.<br /><searchLink fieldCode="AU" term="%22Pobee+A%22">Pobee A</searchLink>; Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.<br /><searchLink fieldCode="AU" term="%22Adu-Amankwah+S%22">Adu-Amankwah S</searchLink>; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.<br /><searchLink fieldCode="AU" term="%22Amoakoh-Coleman+M%22">Amoakoh-Coleman M</searchLink>; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.<br /><searchLink fieldCode="AU" term="%22Amoakoh+HB%22">Amoakoh HB</searchLink>; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.; Department of Global Public Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Abuaku+B%22">Abuaku B</searchLink>; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.<br /><searchLink fieldCode="AU" term="%22Badji+E%22">Badji E</searchLink>; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.<br /><searchLink fieldCode="AU" term="%22Ntiri+M%22">Ntiri M</searchLink>; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.<br /><searchLink fieldCode="AU" term="%22Quaye+L%22">Quaye L</searchLink>; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.<br /><searchLink fieldCode="AU" term="%22Morrow+MP%22">Morrow MP</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Sylvester+AJ%22">Sylvester AJ</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Reuschel+EL%22">Reuschel EL</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Gillespie+E%22">Gillespie E</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Liebowitz+D%22">Liebowitz D</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Humeau+LM%22">Humeau LM</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.
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