Chromatin remodeling enhances MAP3K8 expression in HAM: a key pathogenesis for therapeutic intervention.

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Title: Chromatin remodeling enhances MAP3K8 expression in HAM: a key pathogenesis for therapeutic intervention.
Authors: Nakashima M; Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan., Nagai K; Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan., Takao N; Department of Neurology, St. Marianna University School of Medicine, Kanagawa, Japan., Araya N; Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan., Kuze Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan., Mizuike J; Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan., Tosaka S; Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.; Laboratory of Viral Oncology and Genomics, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan., Aratani S; Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan.; LSI Medience Co, Tokyo, Japan., Yagishita N; Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan., Horibe E; Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan., Watanabe T; Department of Hematology, St. Marianna University School of Medicine, Kanagawa, Japan., Sato T; Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan.; Department of Neurology, St. Marianna University School of Medicine, Kanagawa, Japan., Nannya Y; Division of Hematopoietic Disease Control, The Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Department of Hematology/Oncology, IMSUT Hospital, The Institute of Medical Science, the University of Tokyo, Tokyo, Japan., Suzuki Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan., Uchimaru K; Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan., Yamagishi M; Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan. myamagishi@edu.k.u-tokyo.ac.jp.; Laboratory of Viral Oncology and Genomics, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan. myamagishi@edu.k.u-tokyo.ac.jp., Yamano Y; Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan. yyamano@marianna-u.ac.jp.; Department of Neurology, St. Marianna University School of Medicine, Kanagawa, Japan. yyamano@marianna-u.ac.jp.
Source: Nature communications [Nat Commun] 2025 Nov 10; Vol. 16 (1), pp. 9874. Date of Electronic Publication: 2025 Nov 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Chromatin remodeling enhances MAP3K8 expression in HAM: a key pathogenesis for therapeutic intervention.
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  Data: <searchLink fieldCode="AU" term="%22Nakashima+M%22">Nakashima M</searchLink>; Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Nagai+K%22">Nagai K</searchLink>; Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Takao+N%22">Takao N</searchLink>; Department of Neurology, St. Marianna University School of Medicine, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Araya+N%22">Araya N</searchLink>; Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Kuze+Y%22">Kuze Y</searchLink>; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Mizuike+J%22">Mizuike J</searchLink>; Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tosaka+S%22">Tosaka S</searchLink>; Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.; Laboratory of Viral Oncology and Genomics, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Aratani+S%22">Aratani S</searchLink>; Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan.; LSI Medience Co, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yagishita+N%22">Yagishita N</searchLink>; Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Horibe+E%22">Horibe E</searchLink>; Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+T%22">Watanabe T</searchLink>; Department of Hematology, St. Marianna University School of Medicine, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+T%22">Sato T</searchLink>; Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan.; Department of Neurology, St. Marianna University School of Medicine, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Nannya+Y%22">Nannya Y</searchLink>; Division of Hematopoietic Disease Control, The Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Department of Hematology/Oncology, IMSUT Hospital, The Institute of Medical Science, the University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+Y%22">Suzuki Y</searchLink>; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Uchimaru+K%22">Uchimaru K</searchLink>; Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yamagishi+M%22">Yamagishi M</searchLink>; Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan. myamagishi@edu.k.u-tokyo.ac.jp.; Laboratory of Viral Oncology and Genomics, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan. myamagishi@edu.k.u-tokyo.ac.jp.<br /><searchLink fieldCode="AU" term="%22Yamano+Y%22">Yamano Y</searchLink>; Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan. yyamano@marianna-u.ac.jp.; Department of Neurology, St. Marianna University School of Medicine, Kanagawa, Japan. yyamano@marianna-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Nov 10; Vol. 16 (1), pp. 9874. <i>Date of Electronic Publication: </i>2025 Nov 10.
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