MARCH2-mediated Lys63-linked polyubiquitination promotes metastasis by modulating the catalytic activity of TGF-β type I receptor.

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Title: MARCH2-mediated Lys63-linked polyubiquitination promotes metastasis by modulating the catalytic activity of TGF-β type I receptor.
Authors: Tae K; Department of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea., Cho SW; Department of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea., Lee S; Chemical & Biological Integrative Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea., Heo D; Department of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea., Cha HS; Department of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea., Lee DY; Department of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea., Oh E; Department of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea., Choi M; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea., Shin D; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea., Yang S; Department of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea., Lee C; Chemical & Biological Integrative Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea. clee270@kist.re.kr.; Division of Bio-Medical Science & Technology, KIST school, University of Science and Technology, Seoul, Republic of Korea. clee270@kist.re.kr., Choi CY; Department of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea. choicy@skku.edu.
Source: Cell death & disease [Cell Death Dis] 2025 Nov 10; Vol. 16 (1), pp. 814. Date of Electronic Publication: 2025 Nov 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-025-08145-3